Human Reproduction, Vol 12, 769-773, Copyright © 1997 by Oxford University Press
L Brus, CB Lambalk, J de Koning, MN Helder, RM Janssens and J Schoemaker
In an attempt to resolve the apparent controversy in the observed effects
of gonadotrophin-releasing hormone (GnRH) analogues on the ovary,
conventional binding studies were conducted with a GnRH agonist and an
antagonist in various ovarian tissues to demonstrate possible GnRH receptor
binding. In human luteinized granulosa cells derived from unstimulated
in-vitro fertilization cycles, high affinity receptor binding was present
in 17 out of 24 patients, while binding was not observed in any of the six
pre-ovulatory follicles removed during abdominal surgery. Apparently
contradictory observations on the direct ovarian effects of GnRH analogues
may be the result of the intermittent presence of high affinity GnRH
receptors. Our observations indicate that in the human, high affinity
ovarian GnRH receptors are present predominantly in ovarian tissue after
the luteinizing hormone surge. We also propose the possibility of
regulation and activation of a human follicular GnRH receptor in the ovary
as a physiological process which may be influenced pharmacologically.
ARTICLES
Specific gonadotrophin-releasing hormone analogue binding predominantly in human luteinized follicular aspirates and not in human pre-ovulatory follicles
Research Institute for Endocrinology, Reproduction and Metabolism, Free University Hospital, Amsterdam, The Netherlands.
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