Human Reproduction, Vol 12, 827-829, Copyright © 1997 by Oxford University Press
HI Abdalla, ME Wren, A Thomas and L Korea
The importance of age of the recipient (uterine age) with regards to
pregnancy rate, delivery rate and miscarriage rate following oocyte
donation was evaluated using retrospective data analysis of cases where two
recipients from different age groups shared oocytes from a single donor and
had equal numbers of embryos transferred. A total of 104 women (21-52 years
of age) underwent a total of 104 cycles of oocyte donation. They were
divided into groups according to age (group A: age 39 years or less and
group B: age between 40 and 52 years). The minimum age difference between a
pair of recipients was five years. Hormone replacement therapy (HRT) was
given using oestradiol valerate (6 mg daily) for at least 10 days, followed
by a combination of oestradiol with either intramuscular progesterone (100
mg daily), or vaginally administered micronized progesterone (300 microg
daily). Women with ovarian function received down-regulation using a
luteinizing hormone- releasing hormone (LHRH) analogue before hormone
replacement was commenced. A total of 52 transfer cycles was performed in
each age group and pregnancy, delivery and miscarriage rates were analysed
as outcome measures; 20 pregnancies were achieved in each group (an
identical pregnancy rate of 38.5%). In group A seven pregnancies miscarried
out of 20 (35%), which was not significantly different from the rate in the
older population, group B, where eight out of 20 pregnancies miscarried
(40%). The delivery rate in group A was 25% (13 out of 52), again not
significantly different from the delivery rate in group B of 23.1% (12 out
of 52). In conclusion, using egg donation as a model, the decline in
fecundity with age cannot be explained by uterine factors alone.
ARTICLES
Age of the uterus does not affect pregnancy or implantation rates; a study of egg donation in women of different ages sharing oocytes from the same donor
Lister Hospital, London, UK.
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