Human Reproduction, Vol 12, 1047-1055, Copyright © 1997 by Oxford University Press
J Van Blerkom, M Antczak and R Schrader
Regardless of whether fertilization occurs in vivo or in vitro, a large
proportion of human embryos do not develop progressively through the
pre-implantation stages or arrest development after implantation. This
study examined the association between the chromosomal/spindle normality of
the mature human oocyte and the dissolved oxygen content, vascular
endothelial growth factor concentration (VEGF) and perifollicular blood
flow characteristics of the corresponding ovarian follicles. Findings from
>1000 samples of follicular fluid show that developmentally significant
differences in dissolved oxygen content occur in follicular fluids
aspirated from follicles of equivalent size and ultrasonographic
appearance. Oocytes from severely hypoxic follicles were associated with
high frequencies of abnormalities in the organization of the chromosomes on
the metaphase spindle that could lead to segregation disorders and
catastrophic mosaicisms in the early embryo. Oocytes with cytoplasmic
defects and cleavage stage embryos with multinucleated blastomeres are
derived predominantly from severely hypoxic follicles. VEGF measurements of
follicular fluid and colour pulsed Doppler ultrasonographic analysis of
follicle-specific blood flow characteristics indicated a potentially
important role for this factor both in perifollicular angiogenesis and in
the regulation of intrafollicular oxygen levels. The results are discussed
with respect to how severe intrafollicular hypoxia may influence the
normality of chromosomal organization and segregation in the oocyte, and
whether detailed pulsed Doppler analysis of individual pre-ovulatory
follicles may provide an indirect indication of the 'health' of the
follicle and possibly the developmental competence of the corresponding
oocyte.
ARTICLES
The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  F. J. Broekmans, M. R. Soules, and B. C. Fauser Ovarian Aging: Mechanisms and Clinical Consequences Endocr. Rev., August 1, 2009; 30(5): 465 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Jones and S. S. King Effect of domperidone supplementation of fescue-fed heifers on plasma and follicular fluid fatty acid composition and oocyte quality J Anim Sci, July 1, 2009; 87(7): 2227 - 2238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A R Siddiqui, E L Gastal, M O Gastal, M Almamun, M A Beg, and O J Ginther Relationship of vascular perfusion of the wall of the preovulatory follicle to in vitro fertilisation and embryo development in heifers Reproduction, April 1, 2009; 137(4): 689 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wilding, G. Coppola, B. Dale, and L. Di Matteo Mitochondria and human preimplantation embryo development Reproduction, April 1, 2009; 137(4): 619 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Palomba, A. Falbo, F. Zullo, and F. Orio Jr. Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review Endocr. Rev., February 1, 2009; 30(1): 1 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhou, N. Ohno, N. Terada, S. Saitoh, I. Naito, and S. Ohno Permselectivity of blood follicle barriers in mouse ovaries of the mifepristone-induced polycystic ovary model revealed by in vivo cryotechnique Reproduction, November 1, 2008; 136(5): 599 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Fukuhara, S. Fujii, R. Nakamura, E. Yuzawa, H. Kimura, A. Fukui, and H. Mizunuma Erythrocytes counteract the negative effects of female ageing on mouse preimplantation embryo development and blastocyst formation Hum. Reprod., September 1, 2008; 23(9): 2080 - 2085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Van Blerkom, P. Davis, and V. Thalhammer Regulation of mitochondrial polarity in mouse and human oocytes: the influence of cumulus derived nitric oxide Mol. Hum. Reprod., August 1, 2008; 14(8): 431 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Balaban, B. Ata, A. Isiklar, K. Yakin, and B. Urman Severe cytoplasmic abnormalities of the oocyte decrease cryosurvival and subsequent embryonic development of cryopreserved embryos Hum. Reprod., August 1, 2008; 23(8): 1778 - 1785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P.A. van Montfoort, J. P.M. Geraedts, J. C.M. Dumoulin, A. P.M. Stassen, J. L.H. Evers, and T. A.Y. Ayoubi Differential gene expression in cumulus cells as a prognostic indicator of embryo viability: a microarray analysis Mol. Hum. Reprod., March 1, 2008; 14(3): 157 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Tatone, F. Amicarelli, M. C. Carbone, P. Monteleone, D. Caserta, R. Marci, P. G. Artini, P. Piomboni, and R. Focarelli Cellular and molecular aspects of ovarian follicle ageing Hum. Reprod. Update, March 1, 2008; 14(2): 131 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.M. Banwell, M. Lane, D.L. Russell, K.L. Kind, and J.G. Thompson Oxygen concentration during mouse oocyte in vitro maturation affects embryo and fetal development Hum. Reprod., October 1, 2007; 22(10): 2768 - 2775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gao, C. De Geyter, K. Kossowska, and H. Zhang FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles Mol. Hum. Reprod., July 1, 2007; 13(7): 465 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G P Redding, J E Bronlund, and A L Hart Mathematical modelling of oxygen transport-limited follicle growth Reproduction, June 1, 2007; 133(6): 1095 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. M. Lozano, N. Frydman, J. M. Levaillant, S. Fay, R. Frydman, and R. Fanchin The 3D vascular status of the follicle after HCG administration is qualitatively rather than quantitatively associated with its reproductive competence Hum. Reprod., April 1, 2007; 22(4): 1095 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tatone, M.C. Carbone, S. Falone, P. Aimola, A. Giardinelli, D. Caserta, R. Marci, A. Pandolfi, A.M. Ragnelli, and F. Amicarelli Age-dependent changes in the expression of superoxide dismutases and catalase are associated with ultrastructural modifications in human granulosa cells Mol. Hum. Reprod., November 1, 2006; 12(11): 655 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A R Clark, Y M Stokes, M Lane, and J G Thompson Mathematical modelling of oxygen concentration in bovine and murine cumulus-oocyte complexes. Reproduction, June 1, 2006; 131(6): 999 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kan, E. H. Y. Ng, W. S. B. Yeung, and P. C. Ho Perifollicular vascularity in poor ovarian responders during IVF Hum. Reprod., June 1, 2006; 21(6): 1539 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. T. Merce, S. Bau, M. J. Barco, J. Troyano, R. Gay, F. Sotos, and A. Villa Assessment of the ovarian volume, number and volume of follicles and ovarian vascularity by three-dimensional ultrasonography and power Doppler angiography on the HCG day to predict the outcome in IVF/ICSI cycles Hum. Reprod., May 1, 2006; 21(5): 1218 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. von Otte, J. R. J. Paletta, S. Becker, S. Konig, M. Fobker, R. R. Greb, L. Kiesel, G. Assmann, K. Diedrich, and J.-R. Nofer Follicular Fluid High Density Lipoprotein-associated Sphingosine 1-Phosphate Is a Novel Mediator of Ovarian Angiogenesis J. Biol. Chem., March 3, 2006; 281(9): 5398 - 5405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Marmar and S. Benoff The safety of ultrasonically guided testis aspiration biopsies and efficacy of use to predict varicocelectomy outcome Hum. Reprod., August 1, 2005; 20(8): 2279 - 2288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Bokal, H. M. Vrtovec, I. V. Klun, and I. Verdenik Prolonged HCG action affects angiogenic substances and improves follicular maturation, oocyte quality and fertilization competence in patients with polycystic ovarian syndrome Hum. Reprod., June 1, 2005; 20(6): 1562 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M.R. Gerris Single embryo transfer and IVF/ICSI outcome: a balanced appraisal Hum. Reprod. Update, March 1, 2005; 11(2): 105 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Takeuchi, Q. V. Neri, Y. Katagiri, Z. Rosenwaks, and G. D. Palermo Effect of Treating Induced Mitochondrial Damage on Embryonic Development and Epigenesis Biol Reprod, March 1, 2005; 72(3): 584 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ombelet, P. De Sutter, J. Van der Elst, and G. Martens Multiple gestation and infertility treatment: registration, reflection and reaction--the Belgian project Hum. Reprod. Update, January 1, 2005; 11(1): 3 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pellestor, T. Anahory, and S. Hamamah The chromosomal analysis of human oocytes. An overview of established procedures Hum. Reprod. Update, January 1, 2005; 11(1): 15 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kline, A. Kinney, M.L. Reuss, A. Kelly, B. Levin, M. Ferin, and D. Warburton Trisomic pregnancy and the oocyte pool Hum. Reprod., July 1, 2004; 19(7): 1633 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wu, K. H. Van der Hoek, N. K. Ryan, R. J. Norman, and R. L. Robker Macrophage contributions to ovarian function Hum. Reprod. Update, March 1, 2004; 10(2): 119 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.J. Tozer, R.K. Iles, E. Iammarrone, C.M.Y. Gillott, T. Al-Shawaf, and J.G. Grudzinskas The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome Hum. Reprod., March 1, 2004; 19(3): 522 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Moser, T. Ebner, M. Sommergruber, U. Gaisswinkler, K. Jesacher, M. Puchner, R. Wiesinger, and G. Tews Laser-assisted zona pellucida thinning prior to routine ICSI Hum. Reprod., March 1, 2004; 19(3): 573 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yoshioka, H. Fujiwara, T. Higuchi, S. Yamada, M. Maeda, and S. Fujii Melanoma cell adhesion molecule (MCAM/CD146) is expressed on human luteinizing granulosa cells: enhancement of its expression by hCG, interleukin-1 and tumour necrosis factor-{alpha} Mol. Hum. Reprod., June 1, 2003; 9(6): 311 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ebner, M. Moser, M. Sommergruber, M. Puchner, R. Wiesinger, and G. Tews Developmental competence of oocytes showing increased cytoplasmic viscosity Hum. Reprod., June 1, 2003; 18(6): 1294 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Oehninger and R. G. Gosden Should ICSI be the treatment of choice for all cases of in-vitro conception?: No, not in light of the scientific data Hum. Reprod., September 1, 2002; 17(9): 2237 - 2242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ebner, M. Moser, M. Sommergruber, C. Yaman, U. Pfleger, and G. Tews First polar body morphology and blastocyst formation rate in ICSI patients Hum. Reprod., September 1, 2002; 17(9): 2415 - 2418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Palermo, T. Takeuchi, and Z. Rosenwaks Technical approaches to correction of oocyte aneuploidy Hum. Reprod., August 1, 2002; 17(8): 2165 - 2173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fawzy, A. Lambert, R.F. Harrison, P.G. Knight, N. Groome, B. Hennelly, and W.R. Robertson Day 5 inhibin B levels in a treatment cycle are predictive of IVF outcome Hum. Reprod., June 1, 2002; 17(6): 1535 - 1543. [Abstract] [Full Text] [PDF]
|
|