Human Reproduction, Vol 12, 1188-1190, Copyright © 1997 by Oxford University Press
A Nabi, A Awonuga, H Birch, S Barlow and B Stewart
In this study, we retrospectively analysed data from 877 patients who had
1204 embryo transfer procedures following in-vitro fertilization (IVF) at
Midland Fertility Services, UK, between January 1991 and December 1995 to
investigate the factors contributing to failure of embryo transfer at first
attempt and the impact of immediate retransfer of retained embryos on the
treatment outcome. Embryos were significantly more likely to be retained
when the embryo transfer catheter was contaminated with mucus (3.3 versus
17.8%, P = 0.000001) or blood (3.3 versus 12%, P = 0.00001) and when the
transfer procedure was difficult compared with when it was easy (20.3
versus 0.8%, P = 0.00001). There was no significant difference in the
clinical pregnancy rate between those who had all their embryos transferred
at the first attempt (24.7%) and those who required more than one attempt
(23.2%). The types of embryo transfer catheter used in the unit did not
show any difference in terms of embryo retention. Although we recommend
aspiration of cervical mucus in order to reduce the rate of retained
embryos, there is no evidence from our study to suggest that pregnancy rate
is compromised when embryos are retained, provided they are discovered and
immediately retransferred into the uterine cavity. Immediate retransfer is
more convenient to the patients and reduces the laboratory workload without
compromising the treatment outcome.
ARTICLES
Multiple attempts at embryo transfer: does this affect in-vitro fertilization treatment outcome?
Midland Fertility Services, Aldridge, UK.
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