Human Reproduction, Vol 12, 1430-1433, Copyright © 1997 by Oxford University Press
I Georgiou, M Konstantelli, M Syrrou, IE Messinis and DE Lolis
Experimental evidence has shown that mice lacking the oestrogen receptor
(ESR) gene are infertile with cystic ovaries and follicular arrest. In
humans, several polymorphisms and mutations in the ESR gene have been
identified. In this study we have analysed a common PvuII and a rare BstUI
polymorphism in the ESR gene. Analysis was carried out on DNA samples from
women undergoing ovarian stimulation for in-vitro fertilization (IVF) and
embryo transfer and controls having at least one pregnancy. Comparisons
were done between the three PvuII genotypes, concerning the mean numbers of
follicles and oocytes and the mean ratios of follicles to oocytes harvested
in two consecutive cycles. Significantly lower ratios were identified in
the group lacking the PvuII polymorphism, compared with the groups with
heterozygous or homozygous PvuII polymorphisms (P > 0.05 and P > 0.01
respectively). The rare haplotype having both PvuII and BstUI restriction
sites on one chromosome was present only in the IVF group. Pregnancies from
IVF were significantly rarer in patients who were homozygous for the PvuII
polymorphism (P > 0.05). Our results suggest that genetic variability in
the ESR has a role in the quality of the ovarian follicles as judged by the
ovarian response to stimulation and may also affect implantation.
ARTICLES
Oestrogen receptor gene polymorphisms and ovarian stimulation for in- vitro fertilization
Department of Obstetrics and Gynaecology, Medical School, University of Ioannina, Greece.
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