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Human Reproduction, Vol 12, 1434-1435, Copyright © 1997 by Oxford University Press

ARTICLES

Two successful pregnancies in a 46,XY patient

AK Kan, HI Abdalla and T Oskarsson
Fertility and Endocrinology Centre, In Vitro Fertilisation Unit, Lister Hospital, London, UK.

Two successful pregnancies (singleton followed by twins) following ovum donation/in-vitro fertilization in a 46,XY woman have been studied. Although similar cases have previously been presented: in a pure XY patient and in a 45,X/46,XY patient, this case is one in which a subsequent successful pregnancy has resulted. In such patients, the rate of Caesarean section appears to be increased, and we postulate that the hypoplastic nature of the uterus, although able to respond quite well to both exogenous and endogenous hormones to accept and maintain a pregnancy, may lack the capability to respond fully in labour by dilating appropriately.
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