Human Reproduction, Vol 12, 1629-1634, Copyright © 1997 by Oxford University Press
T Ujioka, K Matsuura, T Kawano and H Okamura
The role of progesterone in capillary permeability, which may be causally
related to the pathophysiology of ovarian hyperstimulation syndrome (OHSS),
was investigated in immature rats. A total of 96 female Wistar rats aged 22
days were given 10 IU of equine chorionic gonadotrophin daily for 4
consecutive days, and given 30 IU of human chorionic gonadotrophin on the
fifth day to produce hyperstimulated manifestations. On the sixth day,
groups of 12 rats each received RU486 at a dose of 0, 1, 2.5, 5, 10, 15 or
20 mg/kg (groups 1-7), or RU486 at 5 mg/kg combined with
6alpha-methyl-17alpha-hydroxy-progesterone acetate at 10 mg/kg (group 8).
On the 7th day, the ovarian weight and capillary permeability of all rats
were determined. Capillary permeability was evaluated from the Evans blue
dye (EB) content in the ovaries and the EB level in peritoneal irrigated
fluid at 30 min after the intravenous injection of EB. The peritoneal fluid
EB level was significantly lower in groups 3, 4, and 5 than in the vehicle
group. However, the peritoneal EB level in group 7 was higher than in the
vehicle group, although not significantly. These findings demonstrated that
RU486 has two divergent effects on capillary permeability, depending on the
dose administered. In group 8, on the other hand, the peritoneal EB level
and ovarian EB content were significantly higher than the corresponding
values in group 4, respectively, suggesting that progesterone has a role in
capillary permeability and ovarian enlargement. These results imply that
progesterone may contribute, at least in part, to the pathophysiology of
OHSS in this experimental model.
ARTICLES
Role of progesterone in capillary permeability in hyperstimulated rats
Department of Obstetrics and Gynaecology, Kumamoto University School of Medicine, Japan.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. R. Soares, R. Gomez, C. Simon, J. A. Garcia-Velasco, and A. Pellicer Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome Hum. Reprod. Update, April 2, 2008; (2008) dmn008v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Gomez, M. Gonzalez-Izquierdo, R. C. Zimmermann, E. Novella-Maestre, I. Alonso-Muriel, J. Sanchez-Criado, J. Remohi, C. Simon, and A. Pellicer Low-Dose Dopamine Agonist Administration Blocks Vascular Endothelial Growth Factor (VEGF)-Mediated Vascular Hyperpermeability without Altering VEGF Receptor 2-Dependent Luteal Angiogenesis in a Rat Ovarian Hyperstimulation Model Endocrinology, November 1, 2006; 147(11): 5400 - 5411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kitajima, T. Endo, K. Nagasawa, K. Manase, H. Honnma, T. Baba, T. Hayashi, H. Chiba, N. Sawada, and T. Saito Hyperstimulation and a Gonadotropin-Releasing Hormone Agonist Modulate Ovarian Vascular Permeability by Altering Expression of the Tight Junction Protein Claudin-5 Endocrinology, February 1, 2006; 147(2): 694 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Gomez, I Lima, C Simon, and A Pellicer Administration of low-dose LH induces ovulation and prevents vascular hyperpermeability and vascular endothelial growth factor expression in superovulated rats Reproduction, April 1, 2004; 127(4): 483 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Aboulghar Prediction of ovarian hyperstimulation syndrome (OHSS): Estradiol level has an important role in the prediction of OHSS Hum. Reprod., June 1, 2003; 18(6): 1140 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Gomez, C. Simon, J. Remohi, and A. Pellicer Administration of Moderate and High Doses of Gonadotropins to Female Rats Increases Ovarian Vascular Endothelial Growth Factor (VEGF) and VEGF Receptor-2 Expression that Is Associated to Vascular Hyperpermeability Biol Reprod, June 1, 2003; 68(6): 2164 - 2171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gomez, C. Simon, J. Remohi, and A. Pellicer Vascular Endothelial Growth Factor Receptor-2 Activation Induces Vascular Permeability in Hyperstimulated Rats, and this Effect Is Prevented by Receptor Blockade Endocrinology, November 1, 2002; 143(11): 4339 - 4348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hatzoglou, K. I. Gourgoulianis, A. Hatzoglou, E. Castanas, and P. A. Molyvdas Rapid effects of 17beta -estradiol and progesterone on sheep visceral and parietal pleurae via a nitric oxide pathway J Appl Physiol, August 1, 2002; 93(2): 752 - 758. [Abstract] [Full Text] [PDF]
|
|