Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (64)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Magoffin, D. A.
Right arrow Articles by Jakimiuk, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Magoffin, D. A.
Right arrow Articles by Jakimiuk, A. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol 12, 1714-1719, Copyright © 1997 by Oxford University Press

ARTICLES

Inhibin A, inhibin B and activin A in the follicular fluid of regularly cycling women

DA Magoffin and AJ Jakimiuk
Department of Obstetrics and Gynecology, CSMC Burns and Allen Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA.

Recent measurements of circulating inhibin A and inhibin B concentrations indicate that inhibin B may play an important role in the selection of dominant follicles. The concentrations of inhibin A, inhibin B and activin A were measured in the follicular fluids of 61 individual follicles (4.8-20 mm in diameter) from 47 regularly cycling women using specific two-site enzyme-linked immunosorbent assays. The microenvironment of each follicle was characterized by measuring follicular fluid androstenedione and oestradiol concentrations. The mean activin A concentrations were < 8 ng/ml for follicles of all sizes (4-17 mm). Inhibin A concentrations were < 1 ng/ml in follicles < 6 mm, and progressively increased to concentrations > 50 ng/ml in follicles > or = 13 mm. Follicles with androstenedione/oestradiol ratios < or = 4 had higher concentrations of inhibin A than follicles with androstenedione/oestradiol ratios > 4. Inhibin B concentrations were higher than inhibin A concentrations in all follicles, increasing from 19.2 +/- 8.3 ng/ml in 4 mm follicles to 409 +/- 9.6 ng/ml in 13 mm follicles and then declining to 275 +/- 47 ng/ml in 17 mm follicles. These results support the hypothesis that inhibin B may play a more important paracrine role in developing follicles and a greater regulatory role with respect to follicle stimulating hormone (FSH) secretion than inhibin A.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
M. R. Sowers, A. D. Eyvazzadeh, D. McConnell, M. Yosef, M. L. Jannausch, D. Zhang, S. Harlow, and J. F. Randolph Jr.
Anti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition
J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3478 - 3483.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Makanji, K. L. Walton, M. C. Wilce, K. L. Chan, D. M. Robertson, and C. A. Harrison
Suppression of Inhibin A Biological Activity by Alterations in the Binding Site for Betaglycan
J. Biol. Chem., June 13, 2008; 283(24): 16743 - 16751.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.L. Haadsma, A. Bukman, H. Groen, E.M.A. Roeloffzen, E.R. Groenewoud, M.J. Heineman, and A. Hoek
The number of small antral follicles (2-6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population
Hum. Reprod., July 1, 2007; 22(7): 1925 - 1931.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Makanji, C. A. Harrison, P. G. Stanton, R. Krishna, and D. M. Robertson
Inhibin A and B in Vitro Bioactivities Are Modified by Their Degree of Glycosylation and Their Affinities to Betaglycan
Endocrinology, May 1, 2007; 148(5): 2309 - 2316.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y. Wang, H. Newton, J. A. Spaliviero, C. M. Allan, B. Marshan, D. J. Handelsman, and P. J. Illingworth
Gonadotropin Control of Inhibin Secretion and the Relationship to Follicle Type and Number in the hpg Mouse
Biol Reprod, October 1, 2005; 73(4): 610 - 618.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
S. Luisi, P. Florio, F. M. Reis, and F. Petraglia
Inhibins in female and male reproductive physiology: role in gametogenesis, conception, implantation and early pregnancy
Hum. Reprod. Update, March 1, 2005; 11(2): 123 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Krishnan, C. Murdock, J. Allard, M. Cisar, E. Reid, L. Nieman, and J. Segars
Pseudo-isolated FSH deficiency caused by an inhibin B-secreting granulosa cell tumour: Case report
Hum. Reprod., March 1, 2003; 18(3): 502 - 505.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. M. Vitale, O. M. Gonzalez, F. Parborell, G. Irusta, S. Campo, and M. Tesone
Inhibin A Increases Apoptosis in Early Ovarian Antral Follicles of Diethylstilbestrol-Treated Rats
Biol Reprod, December 1, 2002; 67(6): 1989 - 1995.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
C. Welt, Y. Sidis, H. Keutmann, and A. Schneyer
Activins, Inhibins, and Follistatins: From Endocrinology to Signaling. A Paradigm for the New Millennium
Experimental Biology and Medicine, October 1, 2002; 227(9): 724 - 752.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.-L. Chang, T.-H. Wang, S.-G. Horng, H.-M. Wu, H.-S. Wang, and Y.-K. Soong
The concentration of inhibin B in follicular fluid: relation to oocyte maturation and embryo development
Hum. Reprod., July 1, 2002; 17(7): 1724 - 1728.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
F.X. Donadeu and O.J. Ginther
Changes in Concentrations of Follicular Fluid Factors During Follicle Selection in Mares
Biol Reprod, April 1, 2002; 66(4): 1111 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Jaatinen, J. Bondestam, T. Raivio, K. Hilden, L. Dunkel, N. Groome, and O. Ritvos
Activation of the Bone Morphogenetic Protein Signaling Pathway Induces Inhibin {beta}B-Subunit mRNA and Secreted Inhibin B Levels in Cultured Human Granulosa-Luteal Cells
J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1254 - 1261.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Newton, Y. Wang, N.P. Groome, and P. Illingworth
Inhibin and activin secretion during murine preantral follicle culture and following HCG stimulation
Hum. Reprod., January 1, 2002; 17(1): 38 - 43.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Fujiwara, Y. Sidis, C. Welt, G. Lambert-Messerlian, J. Fox, A. Taylor, and A. Schneyer
Dynamics of Inhibin Subunit and Follistatin mRNA during Development of Normal and Polycystic Ovary Syndrome Follicles
J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4206 - 4215.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. A. Fowler, T. Sorsa, W. J. Harris, P. G. Knight, and H. D. Mason
Relationship between follicle size and gonadotrophin surge attenuating factor (GnSAF) bioactivity during spontaneous cycles in women
Hum. Reprod., July 1, 2001; 16(7): 1353 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. K. Welt, Z. A. Smith, D. K. Pauler, and J. E. Hall
Differential Regulation of Inhibin A and Inhibin B by Luteinizing Hormone, Follicle-Stimulating Hormone, and Stage of Follicle Development
J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2531 - 2537.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. J. Norman, C. R. Milner, N. P. Groome, and D. M. Robertson
Circulating follistatin concentrations are higher and activin concentrations are lower in polycystic ovarian syndrome
Hum. Reprod., April 1, 2001; 16(4): 668 - 672.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. K. Welt and A. L. Schneyer
Differential Regulation of Inhibin B and Inhibin A by Follicle-Stimulating Hormone and Local Growth Factors in Human Granulosa Cells from Small Antral Follicles
J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 330 - 336.
[Abstract] [Full Text]

Home page
 Mol Hum ReprodHome page
F. M. Reis, A. Faletti, S. Luisi, G. Bifulco, S. Cauci, F. Quadrifoglio, J. Dor, and F. Petraglia
High concentrations of inhibin A and inhibin B in ovarian serous cystadenoma: relationship with oestradiol and nitric oxide metabolites
Mol. Hum. Reprod., December 1, 2000; 6(12): 1079 - 1083.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. L. Schneyer, T. Fujiwara, J. Fox, C. K. Welt, J. Adams, G. M. Messerlian, and A. E. Taylor
Dynamic Changes in the Intrafollicular Inhibin/Activin/Follistatin Axis during Human Follicular Development: Relationship to Circulating Hormone Concentrations
J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3319 - 3330.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
C. Treetampinich, A. E. O'Connor, V. MacLachlan, N. P. Groome, and D. M. de Kretser
Maternal serum inhibin A concentrations in early pregnancy after IVF and embryo transfer reflect the corpus luteum contribution and pregnancy outcome
Hum. Reprod., September 1, 2000; 15(9): 2028 - 2032.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A.L. Mikkelsen, S. Smith, and S. Lindenberg
Impact of oestradiol and inhibin A concentrations on pregnancy rate in in-vitro oocyte maturation
Hum. Reprod., August 1, 2000; 15(8): 1685 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Enskog, L. Nilsson, and M. Brannstrom
Peripheral blood concentrations of inhibin B are elevated during gonadotrophin stimulation in patients who later develop ovarian OHSS and inhibin A concentrations are elevated after OHSS onset
Hum. Reprod., March 1, 2000; 15(3): 532 - 538.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.P. Lau, W.L. Ledger, N.P. Groome, D.H. Barlow, and S. Muttukrishna
Dimeric inhibins and activin A in human follicular fluid and oocyte-cumulus culture medium
Hum. Reprod., October 1, 1999; 14(10): 2525 - 2530.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.