Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (64)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gianaroli, L.
Right arrow Articles by Ferraretti, A. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gianaroli, L.
Right arrow Articles by Ferraretti, A. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol 12, 1762-1767, Copyright © 1997 by Oxford University Press

ARTICLES

Will preimplantation genetic diagnosis assist patients with a poor prognosis to achieve pregnancy?

L Gianaroli, MC Magli, S Munne, A Fiorentino, N Montanaro and AP Ferraretti
S.I.S.M.E.R., Reproductive Medicine Unit, Bologna, Italy.

PGD (preimplantation genetic diagnosis) of aneuploidy for chromosomes X, Y, 13, 18 and 21 was carried out on 196 embryos from 36 infertile patients classified with a poor prognosis due to (i) maternal age, (ii) repeated in-vitro fertilization (IVF) failures and (iii) mosaic karyotype. The percentage of abnormal embryos was comparable in the three groups of patients: maternal age 63%, repeated IVF failure 57%, and mosaic karyotype 62%. The analysis of the overall data revealed an increased incidence of abnormal embryos in the older age categories (predominantly due to aneuploidy), even in embryos at the 7- to 8-cell stage. In addition, the percentage of chromosomally abnormal embryos was directly proportional to the number of IVF failures, where the increase in chromosomal abnormalities was not correlated to aneuploidy but to other aberrations such as mosaicism and polyploidy. Following PGD, 28 patients had at least one embryo transferred that appeared normal by fluorescent in-situ hybridization (FISH). Four clinical pregnancies resulted, with an implantation rate of 10% per normal embryo. In conclusion, the high rate of chromosomally abnormal embryos in poor prognosis patients may have been the cause of implantation failure in their previous IVF cycles. Therefore, the possibility of transferring embryos with a normal FISH complement could improve the chance of pregnancy in this category of patients.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
P. Devroey, B.C.J.M. Fauser, K. Diedrich, and on behalf of the Evian Annual Reproduction (EVAR)
Approaches to improve the diagnosis and management of infertility
Hum. Reprod. Update, July 1, 2009; 15(4): 391 - 408.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Yakin and B. Urman
What next for preimplantation genetic screening? A clinician's perspective
Hum. Reprod., August 1, 2008; 23(8): 1686 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Harper, K. Sermon, J. Geraedts, K. Vesela, G. Harton, A. Thornhill, T. Pehlivan, F. Fiorentino, S. SenGupta, C. de Die-Smulders, et al.
What next for preimplantation genetic screening?
Hum. Reprod., March 1, 2008; 23(3): 478 - 480.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
P. Donoso, C. Staessen, B.C.J.M. Fauser, and P. Devroey
Current value of preimplantation genetic aneuploidy screening in IVF
Hum. Reprod. Update, January 1, 2007; 13(1): 15 - 25.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E.J. Margalioth, A. Ben-Chetrit, M. Gal, and T. Eldar-Geva
Investigation and treatment of repeated implantation failure following IVF-ET
Hum. Reprod., December 1, 2006; 21(12): 3036 - 3043.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Mastenbroek, P. M.M.Bossuyt, M. J. Heineman, S. Repping, and F. van der Veen
Comment 1 on Staessen et al. (2004). Design and analysis of a randomized controlled trial studying preimplantation genetic screening
Hum. Reprod., August 1, 2005; 20(8): 2362 - 2363.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
A.P. Ferraretti, M.C. Magli, L. Kopcow, and L. Gianaroli
Prognostic role of preimplantation genetic diagnosis for aneuploidy in assisted reproductive technology outcome
Hum. Reprod., March 1, 2004; 19(3): 694 - 699.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
T. Pehlivan, C. Rubio, L. Rodrigo, J. Remohi, A. Pellicer, and C. Simon
Preimplantation Genetic Diagnosis by Fluorescence In Situ Hybridiation: Clinical Possibliities and Pitfalls
Reproductive Sciences, September 1, 2003; 10(6): 315 - 322.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
M.G. Katz, A.O. Trounson, and D.S. Cram
DNA fingerprinting of sister blastomeres from human IVF embryos
Hum. Reprod., March 1, 2002; 17(3): 752 - 759.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.C. Magli, G.M. Jones, L. Gras, L. Gianaroli, I. Korman, and A.O. Trounson
Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitro
Hum. Reprod., August 1, 2000; 15(8): 1781 - 1786.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Munne, C. Magli, J. Cohen, P. Morton, S. Sadowy, L. Gianaroli, M. Tucker, C. Marquez, D. Sable, A. P. Ferraretti, et al.
Positive outcome after preimplantation diagnosis of aneuploidy in human embryos
Hum. Reprod., September 1, 1999; 14(9): 2191 - 2199.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G.M. Jones and A.O. Trounson
The benefits of extended culture
Hum. Reprod., June 1, 1999; 14(6): 1405 - 1408.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
M.C. Magli, L. Gianaroli, D. Fortini, A.P. Ferraretti, and S. Munne
Impact of blastomere biopsy and cryopreservation techniques on human embryo viability
Hum. Reprod., March 1, 1999; 14(3): 770 - 773.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.