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Human Reproduction, Vol 12, 1886-1889, Copyright © 1997 by Oxford University Press

ARTICLES

Improved oocyte quality is obtained with follicle stimulating hormone alone than with follicle stimulating hormone/human menopausal gonadotrophin combination

R Mercan, JF Mayer, D Walker, S Jones, S Oehninger, JP Toner and SJ Muasher
The Howard and Georgeanna Jones Institute for Reproductive Medicine, Norfolk, VA 23507, USA.

The aim of this study was to compare the efficacy of pure follicle stimulating hormone (FSH) with that of FSH/human menopausal gonadotrophin (HMG) combination in downregulated cycles. A total of 357 patients was evaluated retrospectively. Sixty percent of patients in the FSH group and 55% in the FSH/HMG group were new; the others were repeat patients. Ovulation was suppressed with leuprolide acetate in all patients, followed by either FSH (n = 218) or FSH/HMG (n = 119). There was no difference in patients' age, infertility factors, number of ampoules used, length of stimulation, oestradiol levels on day of human chorionic gonadotrophin (HCG) administration, number of oocytes recovered or the number of embryos transferred. Also, nuclear maturity at aspiration and fertilization rates were not different between the two groups. FSH stimulation resulted in a significantly higher percentage of mature oocytes that showed the typical 'mature' morphological characteristics (P < 0.0001). The clinical pregnancy rates per transfer were 40 and 28% in patients stimulated with pure FSH and FSH/HMG respectively (P < 0.05). The significantly higher number of immature oocytes matured in vitro in the FSH/HMG group (P = 0.001) suggests a possible effect on in-vitro maturation, due to luteinizing hormone present in HMG. The difference in mature oocyte quality may be an important determinant in the higher pregnancy rates for the FSH- stimulated patients.
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This article has been cited by other articles:


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E. H. Y. Ng, E. Y. L. Lau, W. S. B. Yeung, and P. C. Ho
HMG is as good as recombinant human FSH in terms of oocyte and embryo quality: a prospective randomized trial
Hum. Reprod., February 1, 2001; 16(2): 319 - 325.
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E.S. Sills, D. P. Levy, M. Moomjy, M. McGee, and Z. Rosenwaks
A prospective, randomized comparison of ovulation induction using highly purified follicle-stimulating hormone alone and with recombinant human luteinizing hormone in in-vitro fertilization
Hum. Reprod., September 1, 1999; 14(9): 2230 - 2235.
[Abstract] [Full Text] [PDF]


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