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Human Reproduction, Vol 12, 1913-1914, Copyright © 1997 by Oxford University Press

ARTICLES

Intracytoplasmic sperm injection pregnancy with fetal trisomy 9p resulting from a balanced paternal translocation

D Meschede, F Louwen, B Eiben and J Horst
Institute of Human Genetics, Munster, Germany.

Infertile men who carry a chromosomal translocation can be successfully treated with intracytoplasmic sperm injection (ICSI). However, such treatment carries a risk that a pregnancy with an abnormal karyotype will be induced. While in all previously published cases the outcome was favourable, we here report the first instance of a parental reciprocal translocation leading to a chromosomally unbalanced ICSI pregnancy. The fetus, one of a pair of dizygotic twins, was found to have trisomy for the short arm of chromosome 9. The parents opted for selective abortion of the affected twin.
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