Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lafontan, M.
Right arrow Articles by Berlan, M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lafontan, M.
Right arrow Articles by Berlan, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 12, No. suppl_1, pp. 6-20, 1997
© 1997 European Society of Human Reproduction and Embryology

Adrenergic regulation of adipocyte metabolism

M. Lafontan1, P. Barbe, J. Galitzky, G. Tavernier, D. Langin, C. Carpéné, A. Bousquet-Melou and M. Berlan

Unité INSERM 317, Institut Louis Bugnard, Faculté de Médecine, Université Paul Sabatier Chu Rangueil, 31403 Toulouse Cedex 4, France

Correspondence: 1To whom correspondence should be addressed

Five adrenoceptor (AR) subtypes (β1, β2, β3, {alpha}2 and {alpha}1), are involved in the control of white and brown fat cell function. A number of metabolic events are controlled by the adrenergic system in fat cells. The stimulatory effect of catecholamines on lipolysis and metabolism is mainly connected to increments in cAMP levels, cAMP protein kinase activation and phosphorylation of various target proteins. Norepinephrine and epinephrine operate through differential recruitment of {alpha}2 and β-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is ({alpha}2 > β1 ≥ β2 > β3 for norepinephrine). Antagonistic actions at the level of cAMP production exist between {alpha}2- and β1-, β2- and β3-AR-mediated lipolytic effects in human white fat cells. The role of fat cell ({alpha}2-ARs, which largely outnumber β-ARs in fat cells of certain fat deposits, in human and primate has never been clearly understood. The other AR type which is not linked to lipolysis regulation, the ocrAR, is involved in the control of glycogenolysis and lactate production. Pharmacological approaches using in-situ microdialysis and selective {alpha}2- and β-AR agonists and antagonists have revealed sex- and tissue-specific differences in the adrenergic control of fat cell function and nutritive blood flow in the tissue surrounding the microdialysis probe.

Key words: adipose tissue/β- and {alpha}-adrenoceptors/lactate/glucose transport/lipolysis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Integr. Comp. Biol.Home page
J. S. Torday and V. K. Rehan
Cell-cell signaling drives the evolution of complex traits: introduction--lung evo-devo
Integr. Comp. Biol., August 1, 2009; 49(2): 142 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Dodt, P. Lonnroth, H. L. Fehm, and M. Elam
Intraneural stimulation elicits an increase in subcutaneous interstitial glycerol levels in humans
J. Physiol., December 1, 1999; 521(2): 545 - 552.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.