Human Reproduction, Vol 13, 128-131, Copyright © 1998 by Oxford University Press
J Qiao, WS Yeung, YQ Yao and PC Ho
This study compared the effects of human follicular fluid (hFF) from women
with endometriosis, tubal factor and male factor on the zona binding
capacity of human spermatozoa. Samples of hFF were collected from 30
patients, 10 patients for each of the indications of infertility, at the
time of oocyte retrieval in an in-vitro fertilization/embryo transfer
programme. The hemizona binding assay (HZA) was used to assess the effect
of these hFF on the zona binding potential of human spermatozoa. The mean
numbers of spermatozoa bound to the zona pellucida after treating the
spermatozoa with hFF from endometriosis, tubal factor and male factor were
90.5 +/- 20.9, 108.9 +/- 22.3 and 101.2 +/- 13.4 respectively. These were
significantly lower than their corresponding controls, the spermatozoa of
which were incubated with Earle's balanced salt solution (endometriosis
238.7 +/- 34.7; tubal factor 210.8 +/- 41.6; male factor 205.4 +/- 26.3; P
<0.002). The hemizona binding index (HZI) was similar between male
factor samples (52.0 +/- 6.7) and tubal factor samples (53.8 +/- 4.2).
Spermatozoa incubated with hFF from endometriosis patients (36.0 +/- 4.1)
had an HZI that was significantly lower than those treated with hFF from
tubal factor patients (P <0.01). Probably due to small sample size, the
differences in HZI between endometriosis samples and male factor samples
did not reach statistical significance (P = 0.076). These data suggest that
there was a stronger sperm-zona binding inhibitory effect of hFF from
patients with endometriosis than from those without the disease.
ARTICLES
The effects of follicular fluid from patients with different indications for IVF treatment on the binding of human spermatozoa to the zona pellucida
Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
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