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Human Reproduction, Vol. 13, No. 10, 2688-2692, October 1998
© 1998 European Society of Human Reproduction and Embryology

A comparative prospective study of a chronic low dose versus a conventional ovulation stimulation regimen using recombinant human follicle stimulating hormone in anovulatory infertile women

B. Hedon1, J.N. Hugues2, J.C. Emperaire3, J.J. Chabaud4, D. Barbereau5, A. Boujenah6, C.M. Howles7 and F. Truong8

1 Arnaud de Villeneuve University Hospital, F-34259 Montpellier Cedex 5, France 2 Jean Verdier Hospital, F-93140 Bondy, France 3 Private Institute, F-33000 Bordeaux, France 4 Clinique Pasteur Saint Esprit, F-29200 Brest, France 5 Rhonalpin Institute, F-69500 Bron, France 6 Muette Clinic, F-75016 Paris, France 7 Ares-Serono, Geneva, Switzerland 8 Laboratoires Serono, France

Correspondence: To whom correspondence should be addressed at: Hôpital Universitaire Arnaud de Villeneuve, 371 Avenue Doyer G. Giraud, 34259 Montpellier Cedex 5, France. E-mail: bhiffs{at}mnet.fr

The efficacy and safety of a chronic low dose (group A) and a conventional (group B) stimulation regimen of recombinant human follicle stimulating hormone (r-HFSH) were compared in 103 WHO Group II infertile women with clomiphene citrate-resistant anovulation. Mono- or bifollicular development was induced in 88.1% of patients in group A compared with 76.1% in group B. Ovulation and pregnancy rates were higher in group A (71.4% and 33.3%, respectively) than in group B (63.0% and 20%), but these differences were not statistically significant. Additionally, the total number of follicles that were >10 mm diameter was lower in group A than group B (3.0 ± 2.6 versus 6.3 ± 6.5; P < 0.0001), as was the oestradiol concentration (504 ± 477 pg/ml versus 988 ± 740 pg/ml; P < 0.03). The median dose of FSH (75 IU ampoules) used per cycle was 11 ampoules in group A and 12.5 in group B. In terms of the incidence of ovarian hyperstimulation syndrome, no differences were recorded between the two groups. The results demonstrated that r-HFSH is effective and safe in both these treatment protocols. The chronic low dose regimen was associated with a trend towards a higher rate of mono- or bifollicular development, without jeopardizing the incidence of pregnancy.

Key words: anovulation/induction of ovulation/low-dose/r-HFSH


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