Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Giltay, J.C.
Right arrow Articles by Scheres, J.M.J.C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giltay, J.C.
Right arrow Articles by Scheres, J.M.J.C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 13, No. 10, 2745-2747, October 1998
© 1998 European Society of Human Reproduction and Embryology

Case report: One normal child and a chromosomally balanced/normal twin after intracytoplasmic sperm injection in a male with a de-novo t(Y;16) translocation

J.C. Giltay1, C.H.J. Tiemessen2, W.G. van Inzen2 and J.M.J.C. Scheres1

1 Clinical Genetics Center, Utrecht, The Netherlands 2 Elisabeth Hospital, Tilburg, The Netherlands

Correspondence: To whom correspondence should be addressed at: PO Box 18009, 3501 CA, Utrecht, The Netherlands

A balanced translocation t(Y;16)(q11.21;q24) is described in a male with severe oligoasthenoteratozoospermia (OAT). Before having a chromosome investigation, the patient and his partner had undergone intracytoplasmic sperm injection (ICSI) treatment resulting in the birth of a healthy 46,XX child. After detection of the t(Y;16) translocation, the couple opted for further ICSI treatment, although they were extensively counselled on the risk of having chromosomally unbalanced offspring. This treatment resulted in a twin pregnancy, one with a 46,XX karyotype and the other a 46,X,t(Y;16) (q11.21;q24) karyotype, the same as the father. After an uncomplicated pregnancy two healthy children were born. We conclude that patients with a Y/autosome translocation as a cause of OAT can have chromosomally normal children after ICSI treatment.

Key words: chromosomal abnormalities/ICSI/male infertility/oligoasthenoteratozoospermia (OAT)/Y;autosome translocation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
S. Brisset, V. Izard, M. Misrahi, A. Aboura, S. Madoux, S. Ferlicot, D. Schoevaert, J.C. Soufir, R. Frydman, and G. Tachdjian
Cytogenetic, molecular and testicular tissue studies in an infertile 45,X male carrying an unbalanced (Y;22) translocation: Case report
Hum. Reprod., August 1, 2005; 20(8): 2168 - 2172.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A.L. Buonadonna, F. Cariola, E. Caroppo, A.D. Carlo, P. Fiorente, M.C. Valenzano, G. D'Amato, and M. Gentile
Molecular and cytogenetic characterization of an azoospermic male with a de-novo Y;14 translocation and alternate centromere inactivation
Hum. Reprod., March 1, 2002; 17(3): 564 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Stern, M. Pertile, H. Norris, L. Hale, and H.W.G. Baker
Chromosome translocations in couples with in-vitro fertilization implantation failure
Hum. Reprod., August 1, 1999; 14(8): 2097 - 2101.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.