Human Reproduction, Vol 13, 3326-3331, Copyright © 1998 by Oxford University Press
OB Christiansen, Z Ulcova-Gallova, H Mohapeloa and V Krauz
Autoantibody production is commonly associated with particular HLA class II
phenotypes. The aim of the present study was to investigate whether the
presence of antiphospholipid (APL) antibodies and other autoantibodies in
women with unexplained recurrent miscarriage was associated with particular
human leukocyte antigen (HLA)-DR or -DQ alleles or linked epitopes which
have previously been reported as being associated with the recurrent
miscarriage syndrome or the presence of APL. In a total of 123 Danish and
Czech women with recurrent miscarriage, serum was investigated for six
different APL antibodies including anticardiolipin (ACL) antibody.
Antinuclear antibodies (ANA), anti-zona pellucida antibodies and anti-sperm
antibodies were also investigated. The women were HLA-DR and -DQ typed by
DNA-based methods. The frequency of HLA-DR phenotypes did not differ
significantly between APL antibody positive recurrent miscarriage patients
and APL antibody negative recurrent miscarriage patients or healthy
controls. Among ACL antibody positive recurrent miscarriage patients,
significantly more were positive for the HLA-DR3 phenotype and negative for
the HLA-DR2 phenotypes compared with healthy controls (P < 0.05). Among
ANA positive recurrent miscarriage women, 55% carried the HLA-DR3 phenotype
compared with 28% of ANA negative patients (P < 0.05) and 21% of healthy
controls (P < 0.002). In conclusion, among recurrent miscarriage women,
the HLA-DR3 phenotypes seem to predispose to formation of ACL antibodies
and ANA. The association between APL antibodies and particular HLA alleles
and HLA-linked epitopes reported in studies of patients with lupus
erythematosus (e.g. HLA-DR7 and -DR4) could not be confirmed in patients
with recurrent miscarriage.
ARTICLES
Studies on associations between human leukocyte antigen (HLA) class II alleles and antiphospholipid antibodies in Danish and Czech women with recurrent miscarriages
Department of Obstetrics and Gynaecology, Aalborg Hospital, Denmark.
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