Human Reproduction, Vol 13, 3431-3433, Copyright © 1998 by Oxford University Press
B Balaban, B Urman, A Sertac, C Alatas, S Aksoy and R Mercan
In this study, we compared the fertilization rate and embryo quality after
intracytoplasmic sperm injection (ICSI) as they relate to oocyte
morphology. A total of 654 ICSI cycles yielding 5903 metaphase II oocytes
were observed. The oocytes retrieved in these cycles were divided into (i)
normal oocytes, (ii) oocytes with extracytoplasmic abnormalities (dark zona
pellucida and large perivitelline space), (iii) oocytes with cytoplasmic
abnormalities (dark cytoplasm, granular cytoplasm, and refractile body),
(iv) oocytes with shape abnormalities, and (v) oocytes with more than one
abnormality (double and triple abnormalities). Intracytoplasmic vacuoles
and aggregates of smooth endoplasmic reticulum were not recorded
separately. The fertilization rate and quality of morphologically graded
embryos did not differ between the groups. There were 77 cycles where all
transferred embryos were derived from abnormal oocytes, and 164 cycles
where all embryos were derived from normal oocytes. These cycles were
studied further. The two groups were comparable regarding mean female age,
duration of infertility, duration of ovarian stimulation, number of
ampoules of gonadotrophin injected, and number of oocytes retrieved. Two
clinical pregnancy rates (44.4 versus 42.1%) and implantation rates per
embryo (10.3 versus 13.2%) were similar. In conclusion, in couples
undergoing ICSI, abnormal oocyte morphology is not associated with a
decreased fertilization rate or unfavourable embryo quality. Furthermore,
embryos derived from abnormal oocytes yield similar clinical pregnancy and
implantation rates when transferred compared with embryos derived from
normal oocytes.
ARTICLES
Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection
Assisted Reproductive Technology Unit, American Hospital of Istanbul, Turkey.
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