Human Reproduction, Vol 13, 3460-3468, Copyright © 1998 by Oxford University Press
M Creus, J Balasch, J Ordi, F Fabregues, R Casamitjana, L Quinto, C Coutifaris and JA Vanrell
Integrins have recently been proposed as having a major role in endometrial
receptivity. Different patterns of integrin expression have been described
during the normal endometrial cycle, and the co- expression of several
integrins, mainly alpha1, alpha4 and beta3 has been considered as specific
to the 'window of implantation'. In the present study 55 infertile patients
underwent two endometrial biopsies during a single menstrual cycle. An
early biopsy was done on postovulatory days 6-8, and a late biopsy was
performed on postovulatory days 10 to 12. Histological dating as well as
immunohistochemical evaluation of alpha1, alpha4, beta1, beta3, beta5,
alpha(v)beta3 integrin expression and oestrogen and progesterone receptors
were determined in all endometrial biopsies. Oestradiol and progesterone
serum concentrations in serum were evaluated on the same days of the
endometrial samplings. Nine out of the 55 midluteal biopsies (16.4%) showed
out-of-phase endometria, but all biopsies were in phase in the late luteal
phase. Differences in integrin expression between in- and out-of-phase
biopsies were observed only for alpha(v)beta3 integrin glandular expression
during the midluteal phase. Alpha(v)beta3 integrin glandular expression was
found in all late luteal phase biopsies. Alpha(v)beta3 expression was
closely correlated with histological maturation of the endometrium
appearing suddenly at postovulatory day 6-7 and being expressed by all
endometria dated as postovulatory day > or = 8, irrespective of
midluteal endometrial biopsies being in phase or out of phase. No
differences in integrin expression were detected between patients with or
without endometriosis or between patients who became spontaneously pregnant
and those who did not. In conclusion, further studies are necessary before
patterns of integrin expression may offer an alternative to predict uterine
receptivity and implantation potential.
ARTICLES
Integrin expression in normal and out-of-phase endometria
Department of Obstetrics and Gynecology, Faculty of Medicine-University of Barcelona, Hospital Clinic i Provincial-Institut d'Investigacions Biomediques August Pi i Sunyer, Spain.
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