Human Reproduction, Vol 13, 334-338, Copyright © 1998 by Oxford University Press
SD Spandorfer, OM Avrech, LT Colombero, GD Palermo and Z Rosenwaks
The purpose of this study was to investigate any influence of maternal
and/or paternal age on gamete characteristics and pregnancy outcomes in
intracytoplasmic sperm injection (ICSI) cycles. In all, 821 consecutive
ICSI cases were analysed retrospectively. While a significant linear
decline in semen volume was detected, no significant differences in the
concentration, motility or morphology of the spermatozoa were found with
paternal ageing. A significant decline in the number of oocytes retrieved
and the number of mature oocytes obtained was found with advancing maternal
age. An increase in the occurrence of digyny was noted with parental
ageing, while no difference in single or bipronuclear fertilization was
found. Older women had a decreased incidence of single pronucleus formation
and an increase in digyny, but no significant difference in the percentage
of oocytes that underwent two-pronuclear fertilization was detected with
regard to maternal ageing. Pregnancy outcomes were not influenced by the
age of the male partner, while a strong negative correlation was found with
maternal ageing. To better analyse male partner ageing as a factor
affecting pregnancy outcome, we analysed a subgroup of patients with a
female partner aged <35 years who underwent ICSI. No paternal influence
on ICSI pregnancy outcome was found in this subgroup of patients. We
conclude that the influence on pregnancy outcome after ICSI is related
mostly to maternal and not paternal age.
ARTICLES
Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection
The Center for Reproductive Medicine and Infertility, The New York Hospital-Cornell University Medical College, NY 10021, USA.
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