Human Reproduction, Vol 13, 339-341, Copyright © 1998 by Oxford University Press
J Roest, AM van Heusden, GH Zeilmaker and A Verhoeff
The validity of the cumulative pregnancy rate (CPR) calculated by life-
table approach, obtained in a transport in-vitro fertilization (IVF)
programme, was tested by the determination of possible influence of
selective drop-out of patients with a poor treatment prognosis. A cohort of
1211 patients who had a first IVF cycle was followed, and the CPR after
three IVF cycles was assessed. First cycles of patients who discontinued
treatment after failed IVF, and of those who did not achieve a pregnancy
but proceeded to a subsequent cycle, were compared for fertilization rate
and for occurrence of prognosticators of poor treatment outcome: oocyte
yield < or =2, and replacement of <2 embryos. The CPR after three
cycles was 54.9%. No differences were found in the first and second cycles
of patients who continued treatment and those who dropped out. Selective
drop-out of patients with a poor treatment prognosis was not found.
Therefore, although calculations of CPR using life-table analysis generally
overestimate the real probability of pregnancy after successive IVF cycles,
the calculated CPR after three IVF cycles gives a reliable indication of
the chance of occurrence of a pregnancy for the population studied.
ARTICLES
Cumulative pregnancy rates and selective drop-out of patients in in- vitro fertilization treatment
Department of Obstetrics and Gynaecology, Zuiderziekenhuis, Rotterdam, The Netherlands.
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