Human Reproduction, Vol 13, 342-347, Copyright © 1998 by Oxford University Press
BP Setchell, G Ekpe, JL Zupp and MA Surani
In three separate experiments, using three different strains of mice, when
normal females were mated by males whose testes had been heated once to 42
degrees C for 20 min, the embryos at 10.5 days post-coitum were
approximately 20% smaller than control embryos. In one experiment, the
difference was still present, although proportionately less, at 15.5 and
18.5 days and, in another experiment, a difference could be seen in 11.5
and 13.5 day old embryos but not in 12.5, 14.5, 15.5 or 18.5 day old
embryos. The frequency of mating and pregnancy rates were unaffected. In
one experiment, the time available for mating was restricted to 4 h instead
of overnight, without effect on the result. In another experiment, other
males were heated for 30 min, and these showed a period of infertility from
10 to 32 days later, preceded and followed by the production of smaller
than normal embryos; litter size was also reduced in the period after the
return of fertility in these animals. The yolk sacs and the trophoblasts of
the embryos sired by the heated males were also slightly smaller than those
sired by the controls in the two experiments in which these were measured.
The pattern of weight reduction is thus different from that seen in
gynogenetic embryos or when the gene for insulin-like growth factor
(IGF)-II is disrupted, and suggests a reduction in embryo growth at the
earlier stages, with compensatory growth occurring later in pregnancy.
ARTICLES
Transient retardation in embryo growth in normal female mice made pregnant by males whose testes had been heated
Department of Animal Science, University of Adelaide (Waite), Glen Osmond, S.A., Australia.
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