Human Reproduction, Vol 13, 353-359, Copyright © 1998 by Oxford University Press
FR Ochsendorf, R Buhl, A Bastlein and H Beschmann
Glutathione has a central role in the defence against oxidative damage;
however, the data on glutathione concentrations in the semen of infertile
men are limited. To expand this knowledge the glutathione content of the
ejaculates and blood plasmas of 77 infertile men and 11 controls were
analysed. The concentrations of total glutathione were assessed in
spermatozoa, seminal plasma and blood plasma using a coupled
spectrophotometric assay. In the spermatozoa of patients with
oligozoospermia the glutathione concentrations (2.57+/-0.96 nmol/10[8]
spermatozoa; mean +/- SD) were significantly lower than in the controls
(3.49+/-0.87 nmol/10[8] spermatozoa; P +/- 0.03). The glutathione content
of spermatozoa from patients with normozoospermia showed large variations
(3.04+/-1.37 nmol/10[8] spermatozoa). An association between the
intracellular glutathione content and the ability to penetrate bovine
cervical mucus was observed (r = 0.2, P = 0.04). The intracellular
glutathione concentrations correlated with the glutathione levels in
seminal plasma (r = 0.46, P < 0.0001). There was no correlation between
glutathione concentrations in blood plasma and those in seminal plasma or
in spermatozoa. The glutathione concentrations in seminal plasmas did not
differ between the different groups, however, correlated with the serum
follicle stimulating hormone concentrations (r = 0.53, P = 0.005). This
study demonstrated that intracellular glutathione levels of spermatozoa are
decreased in certain populations of infertile men.
ARTICLES
Glutathione in spermatozoa and seminal plasma of infertile men
Zentrum Dermatologie und Venerologie, Frankfurt am Main, Germany.
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