Human Reproduction, Vol 13, 403-408, Copyright © 1998 by Oxford University Press
CA Croucher, A Lass, R Margara and RM Winston
This study examines the relationship between the first cycle of in- vitro
fertilization (IVF) and subsequent cycles. The results of all IVF cycles
conducted at The Hammersmith Hospital or The Royal Masonic Hospital between
1988 and 1995 were studied including those cycles where egg recovery was
abandoned due to poor ovarian response. All patients underwent a
standardized treatment protocol. Of those women who achieved a clinical
pregnancy during their first IVF attempt, 33% achieved a pregnancy during
their second cycle, statistically significantly different from the 24% of
patients conceiving during a second cycle who had failed to conceive during
their first. 36% of those who achieved a biochemical pregnancy in their
first cycle became pregnant in their second. Age was an important factor in
the success of IVF treatment, with pregnancy rates of 48% in the 20-25 year
age group falling to 8% in those aged > or =41 years. Cumulative
pregnancy rates were 26% after one cycle, increasing to 43% after two
cycles and reached 80% after seven cycles. A previous pregnancy
significantly improved a couple's probability of conception in a later IVF
cycle. Overall pregnancy rates per cycle were constant for the first three
attempts. Cumulative pregnancy rates continued to rise to 72% after six
cycles. Thus the more cycles a couple undergo (up to six) the greater their
chance of a pregnancy.
ARTICLES
Predictive value of the results of a first in-vitro fertilization cycle on the outcome of subsequent cycles
Institute of Obstetrics & Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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