Human Reproduction, Vol 13, 409-413, Copyright © 1998 by Oxford University Press
SE Lanzendorf, F Nehchiri, JF Mayer, S Oehninger and SJ Muasher
The objective of this study was to determine if assisted hatching improved
the rates of implantation, clinical pregnancy and ongoing pregnancy for
in-vitro fertilization (IVF) patients aged > or =36 years. On the day of
oocyte aspiration, consenting patients were randomized according to whether
all embryos underwent the hatching procedure (hatched; n = 41) or all
embryos remained unhatched (controls; n = 48). Patients in both groups were
treated with methylprednisolone and doxycycline starting on the day of
oocyte retrieval and continuing for 4 days. The hatching procedure was
performed approximately 55 h after insemination on all potential embryos
for transfer and employed the release of acidified acid Tyrode's medium
against the zona pellucida to create an opening approximately 20 microm in
diameter. No significant differences were noted in the mean age, number of
oocytes aspirated and number of embryos transferred between the hatched and
control groups. In addition, no significant differences were observed in
the rates of implantation (11.1 versus 11.3%), clinical pregnancy (39.0
versus 41.7%) and ongoing pregnancy (29.3 versus 35.4%) between the hatched
and control groups respectively. These results suggest that assisted
hatching may have no significant impact on IVF success rates in the patient
population studied.
ARTICLES
A prospective, randomized, double-blind study for the evaluation of assisted hatching in patients with advanced maternal age
The Howard and Georgeanna Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23507, USA.
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