Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Grana-Barcia, M.
Right arrow Articles by Aguilar-Fernandez, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grana-Barcia, M.
Right arrow Articles by Aguilar-Fernandez, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol 13, 525-530, Copyright © 1998 by Oxford University Press

ARTICLES

Depression of FSH and LH secretion following pulsatile GnRH administration in ovariectomized women

M Grana-Barcia, J Lado-Abeal, JL Liz-Leston, S Lojo, A Novo-Dominguez and J Aguilar-Fernandez
Department of Obstetrics and Gynaecology, University Hospital Complex, School of Medicine, Santiago de Compostela, Spain.

To investigate the mechanism by which pulsatile administration of gonadotrophin-releasing hormone (GnRH) modifies secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), we studied three groups of five women who had been ovariectomized for non- malignant gynaecological conditions at least 6 months previously, none of whom had received substitutional hormone therapy. Before and after 15 day treatment with subcutaneous pulsatile GnRH (one 20 microg dose every 90 min in group A, one 10 microg dose every 90 min in group B and one 20 microg dose every 120 min in group C), pulsatile secretion of LH and FSH was characterized by determining these hormones in 4 ml blood samples taken every 10 min for 8 h (9.00 a.m. to 5.00 p.m.). For both LH and FSH, mean serum concentration and pulse amplitude were lower after GnRH treatment than before (and in the case of LH the decrease depended upon both the size and frequency of exogenous GnRH pulses) but in no group was there a significant change in LH or FSH pulse frequency. We conclude that exogenous pulsatile GnRH probably acts by partially desensitizing the pituitary rather than by depressing endogenous GnRH secretion. Such partial desensitization would explain reports that exogenous pulsatile GnRH improves ovulation by women with polycystic ovary syndrome.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.