Human Reproduction, Vol 13, 554-560, Copyright © 1998 by Oxford University Press
MB Zelinski-Wooten, JS Hutchison, DL Hess, DP Wolf and RL Stouffer
The efficacy of follicle stimulating hormone (FSH) as an alternative to
luteinizing hormone (LH)/human chorionic gonadotrophin (HCG) for the
initiation of periovulatory events in primate follicles is unknown. A
single bolus of 2500 IU recombinant (r)-hFSH was compared to 1000 IU r- HCG
for its ability to promote oocyte nuclear maturation and fertilization,
granulosa cell luteinization and corpus luteum function following r-hFSH
(60 IU/day) induction of multiple follicular development in rhesus monkeys.
Following the r-hFSH bolus, bioactive luteinizing hormone concentrations
were <3 ng/ml. Peak concentrations of serum FSH (1455+/-314 mIU/ml;
mean+/-SEM) were attained 2-8 h after r-hFSH, and declined by 96 h.
Bioactive HCG concentrations peaked between 2-8 h after r-HCG and remained
> or = 100 ng/ml for >48 h, while immunoreactive FSH concentrations
were at baseline. The proportion of oocytes resuming meiosis and undergoing
in-vitro fertilization (IVF) were comparable for r-hFSH (89%; 47+/-19%) and
r- HCG (88%; 50+/-17%). In-vitro progesterone production and expression of
progesterone receptors in granulosa cells did not differ between groups.
Peak concentrations of serum progesterone in the luteal phase were similar,
but were lower 6-9 days post-FSH relative to HCG. Thus, a bolus of r-hFSH
was equivalent to r-HCG for the reinitiation of oocyte meiosis,
fertilization and granulosa cell luteinization, but a midcycle FSH surge
did not sustain normal luteal function in primates.
ARTICLES
A bolus of recombinant human follicle stimulating hormone at midcycle induces periovulatory events following multiple follicular development in macaques
Oregon Regional Primate Research Center, Beaverton 97006, USA.
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