Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (87)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Meschede, D.
Right arrow Articles by Horst, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meschede, D.
Right arrow Articles by Horst, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol 13, 576-582, Copyright © 1998 by Oxford University Press

ARTICLES

Chromosome abnormalities in 447 couples undergoing intracytoplasmic sperm injection--prevalence, types, sex distribution and reproductive relevance

D Meschede, B Lemcke, JR Exeler, C De Geyter, HM Behre, E Nieschlag and J Horst
Institute of Human Genetics, Munster, Germany.

Chromosomal abnormalities are thought to be a major contributor to the genetic risks of infertility treatment by intracytoplasmic sperm injection (ICSI). Apart from abnormalities arising de novo, abnormal karyotypes in pregnancies conceived through assisted reproductive technology may be directly derived from predisposing parental aberrations. In a prospective study we have analysed the chromosomes of 868 male and female patients prior to planned ICSI treatment. A total of 33 aberrant karyotypes was diagnosed, corresponding to an abnormality rate of 7.6% per couple or 3.8% per individual studied. Even though male factor infertility was twice as common as female factor infertility in this cohort, 24 of the chromosomal abnormalities were found among the women. Low-level mosaicism for numerical sex chromosome anomalies was diagnosed in 20 individuals, and one patient had the triple X karyotype. With respect to structural chromosomal anomalies, we found six reciprocal and three Robertsonian translocations, two paracentric inversions and one marker chromosome. Many of the aberrations that we diagnosed could be classified as carrying only a small to moderate reproductive risk. Given the high rate of abnormal karyotypes among the female subjects, we suggest that not only the males, but both partners should be routinely karyotyped prior to ICSI.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
L. M. Cotton, M. K. O'Bryan, and B. T. Hinton
Cellular Signaling by Fibroblast Growth Factors (FGFs) and Their Receptors (FGFRs) in Male Reproduction
Endocr. Rev., April 1, 2008; 29(2): 193 - 216.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Ravel, I. Berthaut, J.L. Bresson, J. P. Siffroi, and and the Genetics Commission of the French Federati
Prevalence of chromosomal abnormalities in phenotypically normal and fertile adult males: large-scale survey of over 10 000 sperm donor karyotypes
Hum. Reprod., June 1, 2006; 21(6): 1484 - 1489.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
Z. Master
Embryonic stem-cell gametes: the new frontier in human reproduction
Hum. Reprod., April 1, 2006; 21(4): 857 - 863.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E.G. Papanikolaou, V. Vernaeve, E. Kolibianakis, E.V. Assche, M. Bonduelle, I. Liebaers, A. Van Steirteghem, and P. Devroey
Is chromosome analysis mandatory in the initial investigation of normovulatory women seeking infertility treatment?
Hum. Reprod., October 1, 2005; 20(10): 2899 - 2903.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
B. Horsthemke and M. Ludwig
Assisted reproduction: the epigenetic perspective
Hum. Reprod. Update, September 1, 2005; 11(5): 473 - 482.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. Lenz, C.M. Luetjens, A. Kamischke, B. Kuhnert, I. Kennerknecht, and E. Nieschlag
Mosaic status in lymphocytes of infertile men with or without Klinefelter syndrome
Hum. Reprod., May 1, 2005; 20(5): 1248 - 1255.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Clementini, C. Palka, I. Iezzi, L. Stuppia, P. Guanciali-Franchi, and G.M. Tiboni
Prevalence of chromosomal abnormalities in 2078 infertile couples referred for assisted reproductive techniques
Hum. Reprod., February 1, 2005; 20(2): 437 - 442.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Foresta, A. Garolla, L. Bartoloni, A. Bettella, and A. Ferlin
Genetic Abnormalities among Severely Oligospermic Men Who Are Candidates for Intracytoplasmic Sperm Injection
J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 152 - 156.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
J. Gianotten, M.P. Lombardi, A.H. Zwinderman, R. J. Lilford, and F. van der Veen
Idiopathic impaired spermatogenesis: genetic epidemiology is unlikely to provide a short-cut to better understanding
Hum. Reprod. Update, November 1, 2004; 10(6): 533 - 539.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T.E. Schmid, M.H. Brinkworth, F. Hill, E. Sloter, A. Kamischke, F. Marchetti, E. Nieschlag, and A.J. Wyrobek
Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients
Hum. Reprod., June 1, 2004; 19(6): 1395 - 1400.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Aittomaki, U.-B. Wennerholm, C. Bergh, A. Selbing, J. Hazekamp, and K.-G. Nygren
Safety issues in assisted reproduction technology: Should ICSI patients have genetic testing before treatment? A practical proposition to help patient information
Hum. Reprod., March 1, 2004; 19(3): 472 - 476.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Gianotten, G.H. Westerveld, N. J. Leschot, M. W.T. Tanck, R. J. Lilford, M.P. Lombardi, and F. van der Veen
Familial clustering of impaired spermatogenesis: no evidence for a common genetic inheritance pattern
Hum. Reprod., January 1, 2004; 19(1): 71 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L. Rodrigo, C. Rubio, E. Mateu, C. Simon, J. Remohi, A. Pellicer, and M. Gil-Salom
Analysis of chromosomal abnormalities in testicular and epididymal spermatozoa from azoospermic ICSI patients by fluorescence in-situ hybridization
Hum. Reprod., January 1, 2004; 19(1): 118 - 123.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
E. Vicari, A. De Palma, N. Burrello, G. Longo, C. Grazioso, N. Barone, M. Zahi, R. D'agata, and A. E. Calogero
Absolute Polymorphic Teratozoospermia in Patients With Oligo-Asthenozoospermia Is Associated With an Elevated Sperm Aneuploidy Rate
J Androl, July 1, 2003; 24(4): 598 - 603.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
J. Tesarik and C. Mendoza
Using the Male Gamete for Assisted Reproduction: Past, Present, and Future
J Androl, May 1, 2003; 24(3): 317 - 328.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
F. Morel, F. Gallon, V. Amice, M.-J. Le Bris, M.T. Le Martelot, S. Roche, A. Valeri, V. Derrien, A. Herry, J. Amice, et al.
Sex chromosome mosaicism in couples undergoing intracytoplasmic sperm injection
Hum. Reprod., October 1, 2002; 17(10): 2552 - 2555.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Venkataraman and I. Craft
Triple-Y syndrome following ICSI treatment in a couple with normal chromosomes: Case report
Hum. Reprod., October 1, 2002; 17(10): 2560 - 2563.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Bonduelle, I. Liebaers, V. Deketelaere, M.-P. Derde, M. Camus, P. Devroey, and A. Van Steirteghem
Neonatal data on a cohort of 2889 infants born after ICSI (1991-1999) and of 2995 infants born after IVF (1983-1999)
Hum. Reprod., March 1, 2002; 17(3): 671 - 694.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
B. Peterlin, T. Kunej, J. Sinkovec, N. Gligorievska, and B. Zorn
Screening for Y chromosome microdeletions in 226 Slovenian subfertile men
Hum. Reprod., January 1, 2002; 17(1): 17 - 24.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
N. Frydman, S. Romana, M. Le Lorc'h, M. Vekemans, R. Frydman, and G. Tachdjian
Assisting reproduction of infertile men carrying a Robertsonian translocation
Hum. Reprod., November 1, 2001; 16(11): 2274 - 2277.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
B. Sonntag, D. Meschede, V. Ullmann, P. Gassner, J. Horst, E. Nieschlag, and H.M. Behre
Low-level sex chromosome mosaicism in female partners of couples undergoing ICSI therapy does not significantly affect treatment outcome
Hum. Reprod., August 1, 2001; 16(8): 1648 - 1652.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Gekas, F. Thepot, C. Turleau, J.P. Siffroi, J.P. Dadoune, S. Briault, M. Rio, G. Bourouillou, F. Carre-Pigeon, R. Wasels, et al.
Chromosomal factors of infertility in candidate couples for ICSI: an equal risk of constitutional aberrations in women and men
Hum. Reprod., January 1, 2001; 16(1): 82 - 90.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D. Meschede, B. Lemcke, H.M. Behre, Ch. De Geyter, E. Nieschlag, and J. Horst
Clustering of male infertility in the families of couples treated with intracytoplasmic sperm injection
Hum. Reprod., July 1, 2000; 15(7): 1604 - 1608.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D. Meschede, B. Lemcke, H.M. Behre, C.D. Geyter, E. Nieschlag, and J. Horst
Non-reproductive heritable disorders in infertile couples and their first degree relatives
Hum. Reprod., July 1, 2000; 15(7): 1609 - 1612.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Fishel, I. Aslam, F. Lisi, L. Rinaldi, J. Timson, M. Jacobson, L. Gobetz, S. Green, A. Campbell, and R. Lisi
Should ICSI be the treatment of choice for all cases of in-vitro conception?
Hum. Reprod., June 1, 2000; 15(6): 1278 - 1283.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. H. Martin, C. Greene, A. Rademaker, L. Barclay, E. Ko, and J. Chernos
Chromosome analysis of spermatozoa extracted from testes of men with non-obstructive azoospermia
Hum. Reprod., May 1, 2000; 15(5): 1121 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Ogawa, S. Araki, Y. Araki, M. Ohno, and I. Sato
Chromosome analysis of human spermatozoa from an oligoasthenozoospermic carrier for a 13;14 Robertsonian translocation by their injection into mouse oocytes
Hum. Reprod., May 1, 2000; 15(5): 1136 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Geipel, U. Gembruch, M. Ludwig, U. Germer, E. Schwinger, A. Dormeier, and K. Diedrich
Genetic sonography as the preferred option of prenatal diagnosis in patients with pregnancies following intracytoplasmic sperm injection
Hum. Reprod., October 1, 1999; 14(10): 2629 - 2634.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Kamischke, J. Gromoll, M. Simoni, H.M. Behre, and E. Nieschlag
Transmission of a Y chromosomal deletion involving the deleted in azoospermia (DAZ) and chromodomain (CDY1) genes from father to son through intracytoplasmic sperm injection: Case report
Hum. Reprod., September 1, 1999; 14(9): 2320 - 2322.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Stern, M. Pertile, H. Norris, L. Hale, and H.W.G. Baker
Chromosome translocations in couples with in-vitro fertilization implantation failure
Hum. Reprod., August 1, 1999; 14(8): 2097 - 2101.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
Y. H. Lam, W. S. B. Yeung, M. H. Y. Tang, E. H. Y. Ng, W. W. K. So, and P. C. Ho
Maternal serum alpha-fetoprotein and human chorionic gonadotrophin in pregnancies conceived after intracytoplasmic sperm injection and conventional in-vitro fertilization
Hum. Reprod., August 1, 1999; 14(8): 2120 - 2123.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.