Human Reproduction, Vol 13, 656-659, Copyright © 1998 by Oxford University Press
G Fried and H Wramsby
We have analysed the content of the growth and differentiation regulating
peptide, transforming growth factor beta1 (TGFbeta1), in follicular fluid
from patients undergoing in-vitro fertilization (IVF), and correlated
concentrations of TGFbeta1 with the outcome of the IVF treatment and the
concentrations of 17beta oestradiol in serum at ovum retrieval. A total of
88 women with infertility of >3 years duration and age <38 years
participated in the study. During IVF treatment, follicular fluid and
matched serum samples were collected at ovum retrieval and analysed for
TGFbeta1, oestradiol, progesterone, follicle- stimulating hormone (FSH) and
luteinizing hormone (LH) using radioimmunoassay and enzyme-linked
immunosorbent assay. We found that the TGFbeta1 content in the follicular
fluid at the time of oocyte retrieval correlated positively with subsequent
pregnancy. In 29 women who became pregnant following IVF, follicular fluid
TGFbeta1 values were significantly higher (P=0.005) than in 59 women where
IVF was unsuccessful. In the pregnant group, TGFbeta1 values correlated
positively with oestradiol at ovum retrieval. TGFbeta1 also correlated
positively with the number of fertilized oocytes. TGFbeta1 may thus be
important for successful human pre-embryo development, contribute to
successful embryo implantation and development and may be necessary for the
establishment of pregnancy.
ARTICLES
Increase in transforming growth factor beta1 in ovarian follicular fluid following ovarian stimulation and in-vitro fertilization correlates to pregnancy
Department of Women and Child Health, Karolinska Hospital, Stockholm, Sweden.
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