Human Reproduction, Vol 13, 690-695, Copyright © 1998 by Oxford University Press
JA Merriman, DG Whittingham and J Carroll
This study investigates the effects of follicle stimulating hormone (FSH)
or epidermal growth factor (EGF) on the development of mouse oocytes
matured in vitro. The data show that addition of FSH or EGF does not
significantly increase the proportion of oocytes maturing to metaphase II
but does increase the ability of these oocytes to cleave to the 2-cell
stage after fertilization. After transfer of 2-cell embryos to
pseudopregnant recipients, 64-78% of the embryos implanted, which was
significantly reduced compared to embryos from in-vivo matured controls
(89%). Fewer fetuses at day 14 of gestation were produced from embryos
derived from oocytes matured in basal conditions (26%), or in the presence
of EGF (32%), compared to oocytes matured in vivo (64%) or in the presence
of FSH (58%). Examination of polar bodies and pronuclei of oocytes matured
in vitro suggests that an increase in the rate of triploidy may be partly
responsible for the increased fetal loss after maturation in the absence of
FSH. This study shows that the fertilization rate after in-vitro maturation
can be improved by FSH and EGF and that subsequent embryonic development is
improved specifically by FSH.
ARTICLES
The effect of follicle stimulating hormone and epidermal growth factor on the developmental capacity of in-vitro matured mouse oocytes
Department of Anatomy, St George's Hospital Medical School, London, UK.
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