Human Reproduction, Vol 13, 805-809, Copyright © 1998 by Oxford University Press
M Daniely, A Aviram-Goldring, G Barkai and B Goldman
Chromosomal abnormalities (mostly aneuploidy) account for approximately 50%
of fetal losses in the first 8-15 weeks of gestation. Cytogenetic analysis
of aborted fetal material depends on conventional tissue culturing and
karyotyping. This technique is laborious and is subject to problems
including external contamination, culture failure and selective growth of
maternal cells. Comparative genomic hybridization (CGH) was used to
determine the chromosomal constitution of 27 fetuses arising from recurrent
spontaneous abortion. In 12 samples, the CGH results were compared to the
results obtained by conventional cytogenetic techniques. Correlation was
found in 75% of samples. Overall, CGH detected chromosomal abnormalities in
48% of the samples, including trisomies, monosomies, and partial chromosome
gains and losses. The preliminary data in this study show that CGH can be
added, at least as a complementary method, to the traditional cytogenetic
techniques used in the investigation of recurrent spontaneous abortions.
ARTICLES
Detection of chromosomal aberration in fetuses arising from recurrent spontaneous abortion by comparative genomic hybridization
Institute of Human Genetics, Sheba Medical Center, Tel-Hashomer, Ramat- Gan, Israel.
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