Human Reproduction, Vol 13, 890-895, Copyright © 1998 by Oxford University Press
ZP Nagy, H Joris, G Verheyen, H Tournaye, P Devroey and AC Van Steirteghem
The objective of the present study was to analyse the influence of motility
on the results of intracytoplasmic sperm injection (ICSI) when testicular
spermatozoa are used for microinjection and to correlate this with
testicular histology. A total of 197 ICSI treatment cycles (167 couples)
was analysed retrospectively in which testicular spermatozoa were used,
because of complete azoospermia, for microinjection. Fertilization, embryo
cleavage, transfer and pregnancy rates were evaluated and compared in
relation to motility of testicular spermatozoa. In 170 cycles, histological
diagnoses were compared with findings on motility. Injection of motile
testicular spermatozoa (in 159 cycles) provided a higher normal
fertilization rate than did injection of non-motile spermatozoa (in 14
cycles; 65 versus 45% respectively). Normal spermatogenesis was diagnosed
in a significantly higher proportion and incomplete maturation arrest in a
significantly lower proportion in the group of patients in which only
motile spermatozoa were used for microinjection (65 and 10%), as compared
to the group where exclusively non-motile spermatozoa were used (36 and
36%). Fertilization rate after ICSI was relatively high when non-motile
testicular spermatozoa were used for microinjection, but use of motile
testicular spermatozoa was associated with a still higher fertilization
rate (except when histology of the testicular biopsy showed normal
spermatogenesis), and therefore selection of motile testicular spermatozoa
is always preferable for ICSI. Normal spermatogenesis predicts a greater
probability, and maturation arrest a lower probability of recovering motile
testicular spermatozoa.
ARTICLES
Correlation between motility of testicular spermatozoa, testicular histology and the outcome of intracytoplasmic sperm injection
Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), Belgium.
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