Human Reproduction, Vol 13, 916-919, Copyright © 1998 by Oxford University Press
NR Moudgal and MR Sairam
Although the role of follicle stimulating hormone (FSH) in regulating
ovarian function is well accepted, its need in regulating testicular
function of the adult continues to be debated. Sertoli cells of all mammals
have FSH receptors and are known to regulate differentiation and
transformation of germ cells to spermatozoa. However, there appear to be
species and age differences in the way in which FSH regulates
spermatogenesis. An attempt has been made in the current paper to examine
critically the newer data available in support of and against the concept
that FSH is required to regulate spermatogenesis and fertility of the
primate. As there is no evidence to indicate that testicular function in
monkeys and humans is regulated differently, the information available
using the monkey as the experimental surrogate model is discussed in some
depth. These are correlated, wherever feasible, to the newer information
emerging from clinical studies. It appears from these studies that in the
primate (including humans) FSH, besides promoting quantitative
spermatogenesis leading to production of a normal number of spermatozoa,
has a critical role in regulating spermiogenesis, the process that controls
the formation of normal fertilizable mature spermatozoa. While the
requirement for FSH in promoting fertility in the male monkey is reasonably
well established, in humans the evidence currently available in favour of
the concept is still circumstantial and more work needs to be done to
establish the hypothesis beyond any doubt.
REVIEWS
Is there a true requirement for follicle stimulating hormone in promoting spermatogenesis and fertility in primates?
Department of Molecular Reproduction, Development and Genetics, and Jawaharlal Nehru Center for Advanced Scientific Research, Indian Institute of Science, Bangalore.
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