Human Reproduction, Vol 13, 953-959, Copyright © 1998 by Oxford University Press
T Suzuki, H Sasano, R Takaya, T Fukaya, A Yajima and H Nagura
In order to study alterations of angiogenesis and blood vessel regression
through ovarian cycle in human ovaries we quantitatively examined
vascularity in various stages in 24 normal human ovaries. Vascular density
(VD; vessel numbers/10(-7) m2) and endothelial area of each vessel (EA;
10(-12) m2/vessel) were evaluated using immunohistochemistry of CD34 and
CAS 200 image analysis system. Small- sized vessels were sporadically
observed in stroma adjacent to primordial or primary follicles (6.73 +/-
1.83 for VD and 113.58 +/- 21.80 for EA). Formation of capillary network
was observed in the theca layer of preantral follicles (PA; 15.28 +/- 2.77
for VD and 113.58 +/- 21.80 for EA), and higher density of the capillary
network was detected in non-dominant follicles in follicular phase (ND-F)
and dominant follicles (DF; 29.33 +/- 3.84 for VD and 179.69 +/- 41.25 for
EA). Dense capillary network was still present in non-dominant follicles in
luteal phase (ND-L) and atretic follicles (AF; 26.88 +/- 3.36 for VD and
110.88 +/- 50.53 for EA). After ovulation, developing capillaries were also
observed in the luteinized granulosa layers in early corpus luteum (21.95
+/- 2.06 for VD and 167.08 +/- 29.59 for EA). Vessel density markedly
increased in mid corpus luteum, reached plateau in late corpus luteum
(60.85 +/- 5.92 for VD and 70.99 +/- 15.57 for EA) and remained constant
during degenerating corpora lutea. Vascular endothelial growth factor was
immunohistochemically observed in the theca cells in PA, ND-F, DF and ND-L
in follicular stages, and functioning corpora lutea. Immunoreactivity of
intercellular adhesion molecule-1 was detected only in post-capillary
venules in early degenerating corpora lutea. These findings suggest that
ovarian angiogenesis is a requirement for the early stages of
folliculogenesis and luteal growth, and also plays an important role in the
process of follicular atresia and luteal regression.
ARTICLES
Cyclic changes of vasculature and vascular phenotypes in normal human ovaries
Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.
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