Human Reproduction, Vol 13, 1144-1147, Copyright © 1998 by Oxford University Press
JN Anasti, SN Kalantaridou, LM Kimzey, M George and LM Nelson
Vascular endothelial growth factor (VEGF) is a cytokine that induces
angiogenesis. Angiogenesis is a prominent histologic component of the
luteinization process. Luteinization is also characterized by granulosa
cell progesterone secretion in response to the luteinizing hormone (LH)
surge. Local VEGF production in human pre-ovulatory follicles, induced by
LH, was postulated to be a luteinization mediator in women. To investigate
this hypothesis, serum and fluid from the dominant follicle of 31 healthy
regularly cycling multiparous women undergoing laparoscopic sterilization
were obtained. VEGF was measured by enzyme- linked immunosorbent assay, and
LH and progesterone were measured by radioimmunoassay. Follicle aspiration
was performed at a median of 13 days from the last menstrual period (range
11-17 days). The median pre- ovulatory follicle diameter was 16 mm (range
11-23 mm). Follicle fluid VEGF concentrations (mean 6900 pg/ml, range
1200-17 100 pg/ml) were correlated positively with follicle fluid
progesterone concentrations (mean 10 176 nmol/l, range 636-66780 nmol/l,
r=0.62, P=0.002). This correlation was even tighter (r=0.87, P < 0.0001)
when only samples from the 22 women in the earliest stages of follicle
luteinization were considered. In these women serum LH concentrations were
also correlated with follicle fluid VEGF concentrations (r=0.51, P=0.02).
Our findings demonstrate the close dynamic relationship between VEGF
production and early luteinization in human follicles during normal
non-stimulated cycles.
ARTICLES
Human follicle fluid vascular endothelial growth factor concentrations are correlated with luteinization in spontaneously developing follicles
Section on Women's Health, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Q. Huang, A. P. Cheung, Y. Zhang, H.-F. Huang, N. Auersperg, and P. C. K. Leung Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation Am J Physiol Endocrinol Metab, June 1, 2009; 296(6): E1344 - E1353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Jokubkiene, P. Sladkevicius, L. Rovas, and L. Valentin Assessment of changes in volume and vascularity of the ovaries during the normal menstrual cycle using three-dimensional power Doppler ultrasound Hum. Reprod., October 1, 2006; 21(10): 2661 - 2668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Turner, A. L. Harris, S. Melmed, and J. A. H. Wass Angiogenesis in Endocrine Tumors Endocr. Rev., October 1, 2003; 24(5): 600 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Danforth, L. K. Arbogast, S. Ghosh, A. Dickerman, R. Rofagha, and C. I. Friedman Vascular Endothelial Growth Factor Stimulates Preantral Follicle Growth in the Rat Ovary Biol Reprod, May 1, 2003; 68(5): 1736 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Thiruppathi, S. Shatavi, J.A. Dias, E. Radwanska, and J.L. Luborsky Gonadotrophin receptor expression on human granulosa cells of low and normal responders to FSH Mol. Hum. Reprod., August 1, 2001; 7(8): 697 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.L. Benifla, A.F. Bringuier, C. Sifer, R. Porcher, P. Madelenat, and G. Feldmann Vascular endothelial growth factor, platelet endothelial cell adhesion molecule-1 and vascular cell adhesion molecule-1 in the follicular fluid of patients undergoing IVF Hum. Reprod., July 1, 2001; 16(7): 1376 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.M. Hazzard, T.A. Molskness, C.L. Chaffin, and R.L. Stouffer Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval Mol. Hum. Reprod., December 1, 1999; 5(12): 1115 - 1121. [Abstract] [Full Text] [PDF]
|
|