Human Reproduction, Vol 13, 1152-1156, Copyright © 1998 by Oxford University Press
IE Messinis, S Milingos, K Zikopoulos, G Kollios, K Seferiadis and D Lolis
It has been reported that oestradiol may play a role in the production of
leptin from adipocytes. To investigate this relationship further, nine
normally ovulating women were studied during two menstrual cycles, i.e. an
untreated spontaneous cycle and a cycle treated with follicle stimulating
hormone (FSH) from cycle day 2 until the day of human chorionic
gonadotrophin (HCG) injection. Serum leptin values on cycle day 2 did not
differ significantly between the spontaneous and the FSH cycles. In the
spontaneous cycles, leptin values declined gradually and significantly up
to day 7 and then increased progressively up to the day of luteinizing
hormone (LH) surge onset, at which point they achieved the highest values.
In the FSH cycles, serum leptin values increased gradually and
significantly up to day 6, remaining stable thereafter, and were in the
midfollicular phase significantly higher than in the spontaneous cycles.
Significant positive correlations were found between mean values of leptin
and mean values of oestradiol during the second half of the follicular
phase in the spontaneous cycles and during the first half in the FSH
cycles. A significant negative correlation was found between these two
parameters in the spontaneous cycles during the first half of the
follicular phase. Serum leptin levels were significantly higher in the
midluteal than in the follicular phase in both cycles. These results
demonstrate for the first time significant changes in leptin values during
the follicular phase of the human menstrual cycle and a significant
increase during superovulation induction with FSH. It is suggested that
oestradiol may be involved in the regulation of leptin production in women.
ARTICLES
Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone
Department of Obstetrics and Gynaecology, University of Thessalia, Larissa, Greece.
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