Human Reproduction, Vol 13, 1437-1441, Copyright © 1998 by Oxford University Press
AA Kyei-Mensah, S LinTan, J Zaidi and HS Jacobs
The aim of this study was to investigate of the relationship of ovarian
stromal volume, measured using three-dimensional ultrasound, to serum
androgen concentrations in patients with polycystic ovaries. Serum
gonadotrophin, oestradiol and androgen concentrations and ovarian volume
measurements were obtained in the early follicular phase from 100 women
undergoing assisted conception treatment cycles. Group 1 contained 50 women
with regular menstrual cycles and normal ovarian morphology, group 2
contained 24 women with regular menstrual cycles and polycystic ovaries
seen on ultrasound scan and group 3 contained 26 women with polycystic
ovary syndrome. Statistical analysis included analysis of variance,
Scheffe's procedure and Pearson's correlation. Total ovarian volume
(15.7-16.1 versus 11 ml, P < 0.05), stromal volume (14.5 versus 9.4 ml,
P < 0.05) and thecal steroid concentrations were significantly greater
in groups 2 and 3. Stromal volume was positively correlated with serum
androstenedione concentrations (r = 0.45, P = 0.0019 in group 3) but was
not correlated with any other endocrine parameter. It was concluded that
polycystic ovaries are characterized by increased ovarian stroma with
associated overproduction of theca- derived steroids, particularly
androstenedione.
ARTICLES
Relationship of ovarian stromal volume to serum androgen concentrations in patients with polycystic ovary syndrome
The London Women's Clinic, University College London Hospitals, UK.
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