Human Reproduction, Vol 13, 1442-1448, Copyright © 1998 by Oxford University Press
I Schipper, FH de Jong and BC Fauser
The gradual increase in follicle stimulating hormone (FSH) concentrations
in women approaching menopause results from the depletion of the ovarian
follicular pool, a process referred to as 'ovarian ageing'. This study
investigates whether variable endogenous FSH concentrations, as have been
observed in normo-ovulatory young women, are related to menstrual cycle
characteristics, including predictors of ovarian ageing. Serum
concentrations of immunoreactive FSH, oestradiol, and inhibin-A and
inhibin-B were measured, and follicular growth was assessed by transvaginal
ultrasound throughout the follicular phase in 39 healthy volunteers (20-35
years) with regular menstrual cycles. Median serum FSH concentration on
cycle day 3 was 5.1 IU/l (range 3.6-11.2), and median maximum follicular
phase FSH was 6.2 IU/l (range 4.3-11.2), observed on cycle day 6 (range
2-15). Maximum FSH concentrations were not correlated with age or cycle
length, nor with maximum inhibin-B. The number of small (<10 mm) antral
follicles on cycle day 3 was 11 (range 4-21) and was not correlated with
age, nor with maximum FSH. Inhibin-A remained low until a significant rise
on cycle day 9 (range 3-12), which was significantly correlated with the
late follicular rise in oestradiol (r = 0.56, P = 0.01). These observations
indicate a lack of correlation between maximum follicular phase serum FSH
concentrations and parameters of ovarian ageing in women under the age of
35 years. In addition, FSH concentrations assessed on cycle day 3 represent
an underestimation of maximum early follicular phase FSH. Distinct
individual differences in intra-ovarian modification of FSH action,
resulting in differences in the FSH threshold for stimulation of ovarian
function, may be operative.
ARTICLES
Lack of correlation between maximum early follicular phase serum follicle stimulating hormone concentrations and menstrual cycle characteristics in women under the age of 35 years
Department of Obstetrics and Gynaecology, Dijkzigt Academic Hospital and Erasmus University Medical School, Rotterdam, The Netherlands.
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