Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hughes, E. G.
Right arrow Articles by Gunby, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hughes, E. G.
Right arrow Articles by Gunby, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol 13, 1527-1531, Copyright © 1998 by Oxford University Press

ARTICLES

A randomized controlled trial of three low-dose gonadotrophin protocols for unexplained infertility

EG Hughes, JA Collins and J Gunby
McMaster University, Hamilton, Ontario, Canada.

This randomized controlled trial assessed which of three low-intensity ovulation induction protocols was associated with the highest rate of cycle completion among infertile women undergoing intrauterine insemination (IUI) with their husband's spermatozoa. Sixty-three women aged < or = 42 years with normospermic partners participated in the study. The primary diagnosis of infertility was unexplained in 89% of subjects, endometriosis in 6% and tubal factor in 5%. Women were assigned to three groups according to recombinant FSH dosage: group A received two ampoules (75 IU FSH per ampoule) on cycle day 4, and one ampoule on days 6 and 8 (total four ampoules); group B received two ampoules on days 4, 6 and 8 (total six ampoules); group C received two ampoules on days 4, 6, 8 and 10 (total eight ampoules). Daily ultrasound investigations began on cycle day 9-12 and human chorionic gonadotrophin (HCG) 5000 IU was administered when one or two follicles > or = 18 mm were seen. IUI was scheduled for the next day. HCG was given and/or ovulation shown to have occurred in 88 of 109 cycles attempted (81%) with no differences among the three dose groups. Two singleton pregnancies occurred (2.3% per ovulatory cycle and 1.8% per cycle start). There were no significant differences among the three regimes in terms of cycle parameters, suggesting that an individualized and more intensive approach to ovarian stimulation is necessary for many women with unexplained infertility.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
M.M.E. van Rumste, I.M. Custers, F. van der Veen, M. van Wely, J.L.H. Evers, and B.W.J. Mol
The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: a meta-analysis
Hum. Reprod. Update, November 1, 2008; 14(6): 563 - 570.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Allegra, A. Marino, F. Coffaro, P. Scaglione, F. Sammartano, G. Rizza, and A. Volpes
GnRH antagonist-induced inhibition of the premature LH surge increases pregnancy rates in IUI-stimulated cycles. A prospective randomized trial
Hum. Reprod., January 1, 2007; 22(1): 101 - 108.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.B. Lambalk, A. Leader, F. Olivennes, M.R. Fluker, A. N. Andersen, J. Ingerslev, Y. Khalaf, C. Avril, J. Belaisch-Allart, R. Roulier, et al.
Treatment with the GnRH antagonist ganirelix prevents premature LH rises and luteinization in stimulated intrauterine insemination: results of a double-blind, placebo-controlled, multicentre trial
Hum. Reprod., March 1, 2006; 21(3): 632 - 639.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A.J. Goverde, C.B. Lambalk, J. McDonnell, R. Schats, R. Homburg, and J.P.W. Vermeiden
Further considerations on natural or mild hyperstimulation cycles for intrauterine insemination treatment: effects on pregnancy and multiple pregnancy rates
Hum. Reprod., November 1, 2005; 20(11): 3141 - 3146.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
M. A. Bedaiwy, R. K. Sharma, T. K. Alhussaini, M. S. Mohamed, A. M. A. Aleem, D. R. Nelson, A. J. Thomas Jr, and A. Agarwal
The Use of Novel Semen Quality Scores to Predict Pregnancy in Couples With Male-Factor Infertility Undergoing Intrauterine Insemination
J Androl, May 1, 2003; 24(3): 353 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
F.P. Hohmann, J.S.E. Laven, F.H. de Jong, M.J.C. Eijkemans, and B.C.J.M. Fauser
Low-dose exogenous FSH initiated during the early, mid or late follicular phase can induce multiple dominant follicle development
Hum. Reprod., May 1, 2001; 16(5): 846 - 854.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Nuojua-Huttunen, C. Tomas, R. Bloigu, L. Tuomivaara, and H. Martikainen
Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome
Hum. Reprod., March 1, 1999; 14(3): 698 - 703.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.