Human Reproduction, Vol 13, 1819-1824, Copyright © 1998 by Oxford University Press
Y Yaron, Y Ochshorn, A Amit, A Kogosowski, I Yovel and JB Lessing
There are numerous studies concerning pregnancy rates in oocyte donation,
yet only a handful report the obstetric outcome in such pregnancies. The
purpose of this study was to assess factors that influence pregnancy rates,
to determine the incidence of complications, and to evaluate obstetric
outcome in pregnancies resulting from oocyte donation. This study included
423 oocyte recipients who underwent 1001 oocyte donation cycles at the
Oocyte Donation Programme, In-Vitro Fertilization (IVF)-Embryo Transfer
Unit, Herzlia Medical Center, Israel. Donors were all healthy women < 34
years old who underwent IVF themselves. In 873 cycles, fertilization
occurred and embryo transfer was performed, resulting in 194 clinical
pregnancies. Pregnancy rates (PR) significantly declined with the increase
in number of previous attempts, and with increasing age of recipient
(36.8%/embryo transfer in patients < or = 30 compared to 17.8% in
patients > 40 years old). A significant increment in PR was noted with
the increasing number of embryos transferred. The overall PR was
22.2%/embryo transfer. However, in young amenorrhoeic patients with normal
karyotypes undergoing their first cycle, PR was 52.2%; the 'take home baby'
rate was 38.3% per patient undergoing embryo transfer and 17.8% per embryo
transfer cycle. A significant increase in the incidence of
pregnancy-induced hypertension and a higher proportion of abortions were
noted in older patients. A significantly higher incidence of prematurity
and low birthweight was observed in multiple pregnancies.
ARTICLES
Oocyte donation in Israel: a study of 1001 initiated treatment cycles
In Vitro Fertilization/Embryo Transfer Unit, Lis Maternity Hospital, Sourasky Medical Center/Sackler Faculty of Medicine, Tel Aviv University, Israel.
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