Human Reproduction, Vol 13, 1825-1830, Copyright © 1998 by Oxford University Press
MG Hull, JA Williams, B Ray, EA McLaughlin, VA Akande and WC Ford
This study aims to determine the relative contribution of oocyte and/or
sperm dysfunction to the reduction of fertilization rates in vitro in cases
of minor endometriosis and prolonged unexplained infertility. The results
of in-vitro fertilization (IVF) treatment with ovarian stimulation have
been compared between couples with the above conditions and women with
tubal infertility (as control for oocyte function) and the use of donor
spermatozoa (as control for sperm function). Fertilization and cleavage
rates using husband's spermatozoa were significantly reduced in
endometriosis couples (56%, n = 194, P < 0.001) and further
significantly reduced in couples with unexplained infertility (52%, n =
327, P < 0.001) compared with tubal infertility (60%, n = 509). Using
donor spermatozoa the rates were the same as using husband's spermatozoa in
tubal infertility (61%, n = 27) or endometriosis (55%, n = 21) but
significantly though only partly improved with unexplained infertility
(57%, n = 60, P < 0.02). In unexplained infertility, a significantly
increased proportion of couples experienced complete failure of
fertilization and cleavage in a cycle (5-6% versus 2-3%). However, complete
failure was not usually repetitive, and the affected couples did not
account for the overall reduction in fertilization and cleavage rates,
which remained significantly lower in the rest of the unexplained and
endometriosis groups. Implantation and pregnancy rates appeared similar in
all groups. The benefit of IVF treatment in cases of minor endometriosis
and prolonged unexplained infertility is due to superabundance of oocytes
obtained by stimulation. The reduction in natural fertility associated with
endometriosis appears to be at least partly due to a reduced fertilizing
ability of the oocyte. In unexplained infertility, there is distinct
impairment due to otherwise unsuspected sperm dysfunction but probably also
oocyte dysfunction.
ARTICLES
The contribution of subtle oocyte or sperm dysfunction affecting fertilization in endometriosis-associated or unexplained infertility: a controlled comparison with tubal infertility and use of donor spermatozoa
University of Bristol, Centre for Reproductive Medicine, Division of Obstetrics and Gynaecology, St Michael's Hospital, UK.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. Aghajanova, K. Bjuresten, S. Altmae, B.-M. Landgren, and A. Stavreus-Evers HB-EGF but Not Amphiregulin or Their Receptors HER1 and HER4 Is Altered in Endometrium of Women With Unexplained Infertility Reproductive Sciences, May 1, 2008; 15(5): 484 - 492. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Sifer, T. Sasportes, V. Barraud, C. Poncelet, J. Rudant, R. Porcher, I. Cedrin-Durnerin, B. Martin-Pont, J.N. Hugues, and J.P. Wolf World Health Organization grade 'a' motility and zona-binding test accurately predict IVF outcome for mild male factor and unexplained infertilities Hum. Reprod., October 1, 2005; 20(10): 2769 - 2775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kunz, D. Beil, P. Huppert, M. Noe, S. Kissler, and G. Leyendecker Adenomyosis in endometriosis--prevalence and impact on fertility. Evidence from magnetic resonance imaging Hum. Reprod., August 1, 2005; 20(8): 2309 - 2316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Omland, T. Abyholm, P. Fedorcsak, G. Ertzeid, N. B. Oldereid, S. Bjercke, and T. Tanbo Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility Hum. Reprod., March 1, 2005; 20(3): 722 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Akande, L. P. Hunt, D. J. Cahill, and J. M. Jenkins Differences in time to natural conception between women with unexplained infertility and infertile women with minor endometriosis Hum. Reprod., January 1, 2004; 19(1): 96 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Check What role does decreased ovarian reserve play in the aetiology of infertility related to endometriosis? Hum. Reprod., March 1, 2003; 18(3): 653 - 654. [Full Text] [PDF]
|
|
|
|
|
|
D.J. Cahill What is the optimal medical management of infertility and minor endometriosis?: Analysis and future prospects Hum. Reprod., May 1, 2002; 17(5): 1135 - 1140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.K. Omland, P. Fedorcsak, R. Storeng, P.O. Dale, T. Abyholm, and T. Tanbo Natural cycle IVF in unexplained, endometriosis-associated and tubal factor infertility Hum. Reprod., December 1, 2001; 16(12): 2587 - 2592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Carlberg, J. Nejaty, B. Froysa, Y. Guan, O. Soder, and A. Bergqvist Elevated expression of tumour necrosis factor {alpha} in cultured granulosa cells from women with endometriosis Hum. Reprod., June 1, 2000; 15(6): 1250 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C.M. Dumoulin, E. Coonen, M. Bras, L. C.P. van Wissen, R. Ignoul-Vanvuchelen, J.M. Bergers-Jansen, J. G. Derhaag, J. P.M. Geraedts, and J. L.H. Evers Comparison of in-vitro development of embryos originating from either conventional in-vitro fertilization or intracytoplasmic sperm injection Hum. Reprod., February 1, 2000; 15(2): 402 - 409. [Abstract] [Full Text] [PDF]
|
|