Human Reproduction, Vol 13, 1901-1906, Copyright © 1998 by Oxford University Press
O Salha, D Nugent, T Dada, S Kaufmann, S Levett, L Jenner, S Lui and V Sharma
As a consequence of multiple follicular growth during ovarian stimulation
for in-vitro fertilization (IVF), follicles of varying sizes often yield
oocytes that vary in maturity and morphology of the oocyte-cumulus-corona
complex. The objective of this prospective study was to explore the
relationship between follicular fluid aspirate volume and the oocyte's
developmental potential in an IVF treatment cycle. In total 9933 follicles
were studied from 400 patients who underwent 535 consecutive IVF treatment
cycles at St James's University Hospital, Leeds, UK, between February 1995
and February 1996. The volume of each individual follicle aspirated was
recorded and related to the probability of obtaining an oocyte, its
fertilizing capacity, the cleavage rate and the quality of embryos derived.
We found no statistically significant difference in oocyte recovery rates
between follicles with an aspirate volume < or = 1 ml and follicles with
a volume > 1 ml. Although oocytes obtained from follicles with an
aspirate volume > or = 1 ml showed a significantly lower fertilization
rate, they went on to cleave at the same rate as oocytes obtained from
larger follicles and resulted in embryos of comparable quality.
Furthermore, there was no statistically significant difference in the
implantation, clinical pregnancy or live birth rates per cycle between
embryos derived from follicles with an aspirate volume < or = 1 ml and
those derived from follicles with an aspirate volume > 1 ml. We conclude
that follicular size and the oocyte's developmental potential in the
stimulated ovary are not closely related and can be independent. This is in
contrast to the Graafian follicle and the pre-ovulatory oocyte in the
natural cycle.
ARTICLES
The relationship between follicular fluid aspirate volume and oocyte maturity in in-vitro fertilization cycles
The Assisted Conception Unit, St James's University Hospital, Leeds, UK.
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