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Human Reproduction, Vol. 13, No. suppl_1, pp. 186-195, 1998
© 1998 European Society of Human Reproduction and Embryology

Clinical experience with preimplantation genetic diagnosis and intracytoplasmic sperm injection

I. Liebaers1,3, K. Sermon1, C. Staessen2, H. Joris2, W. Lissens1, E. Van Assche1, P. Nagy2, M. Bonduelle1, M. Vandervorst2, P. Devroey2 and A. Van Steirteghem2

1 Centre for Medical Genetics, Dutch-speaking Brussels Free University Laarbeeklaan 101, 1090 Brussels, Belgium 2 Centre for Reproductive Medicine, Dutch-speaking Brussels Free University Laarbeeklaan 101, 1090 Brussels, Belgium

Correspondence: 3To whom correspondence should be addressed

Preimplantation genetic diagnosis (PGD) is a novel procedure whose use may be considered to obtain a very early prenatal diagnosis for couples at risk for transmitting genetic diseases. Using the polymerase chain reaction (PCR) or fluorescence in-situ hybridization (FISH) the genotype or the sex of biopsied cleavage-stage embryos obtained after in-vitro fertilization can be determined and selected embryos can then be transferred. In-vitro fertilization with intracytoplasmic sperm injection is the method of choice to obtain embryos to be analysed through PCR to reduce contamination by residual sperm DNA. In our series of 61 PGD cycles for 29 couples at risk over a period of 4 years the ongoing pregnancy rate per cycle was 15%, per transfer 19% and per patient 31%. One of the six morphologically normal children born, who is still alive and doing well, weighed 850 g after birth at 25 weeks following a complicated triplet pregnancy. More experience is needed to correctly evaluate the efficiency and safety of this novel technique as well as to determine its place in the prevention of genetic disease.

Key words: intracytoplasmic sperm injection/monogenic diseases/preimplantation genetic diagnosis


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