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Human Reproduction, Vol. 13, No. suppl_1, pp. 51-61, 1998
© 1998 European Society of Human Reproduction and Embryology

Diagnostic tools in male infertility

Christopher L.R. Barratt1 and Justin C. St John

University Department of Obstetrics and Gynaecology, Birmingham Women's Hospital Edgbaston, Birmingham B15 2TG, UK

Correspondence: 1To whom correspondence should be addressed

This review critically analyses the diagnostic value of conventional semen analysis and sperm function testing. It is clear from the data available that a high quality comprehensive semen assessment is a basic requirement in the diagnosis of the infertile couple. Sperm function testing has given disappointing results and a new generation of sperm function tests is required, which are cost effective, reliable and provide clinically significant information. In the future there will be an increasing use of molecular techniques to diagnose male infertility. Specific attention is given to the role of polymerase chain reaction in the diagnosis of genital infection and Y chromosomal and mitochondrial DNA deletions as examples.

Key words: mitochondria/PCR/spermatozoa/Y chromosome/zona pellucida


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