Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Liesnard, C.A.
Right arrow Articles by Englert, Y.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Liesnard, C.A.
Right arrow Articles by Englert, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 13, No. suppl_2, pp. 25-31, 1998
© 1998 European Society of Human Reproduction and Embryology

Is matching between women and donors feasible to avoid cytomegalovirus infection in artificial insemination with donor semen?

C.A. Liesnard1,3, P. Revelard2 and Y. Englert2

1 Laboratory of Virology, Department of Obstetrics and Gynecology, Hôpital Erasme, Université Libre de Bruxelles Brussels 1070, Belgium 2 Fertility Clinic, Department of Obstetrics and Gynecology, Hôpital Erasme, Université Libre de Bruxelles Brussels 1070, Belgium

Correspondence: 3To whom correspondence should be addressed

Cytomegalovirus (CMV) is the most common cause of congenital infection responsible for neonatal mortality, morbidity and later sequelae. Primary infection in the first half of pregnancy seems to have the worst outcome. CMV has been frequently recovered from human semen. In the setting of artificial insemination with semen donors, matching recipients and donors for CMV antibodies with the purpose of reserving seronegative semen for seronegative women is a recommended strategy to avoid the risk of a primary maternal CMV infection during pregnancy. We have reviewed the CMV seroprevalence in semen donors and candidates for insemination in our centre, and compared it with the CMV seroprevalence of blood donors. Without matching for CMV antibodies, the risk of a seronegative recipient being inseminated with seropositive semen was 21%. The same risk calculated for blood donors was 17%. Matching semen donors and recipients for CMV antibodies is possible as, in our study, 48% of the recipients and 55% of the donors were seronegative. During serological follow-up of CMV seronegative individuals in the fertility centre, no seroconversion was observed among donors; two seroconversions occurred in recipients, but not in relationship to therapeutic inseminations.

Key words: artificial insemination/cytomegalovirus


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.