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Human Reproduction, Vol. 13, No. suppl_4, pp. 173-183, 1998
© 1998 European Society of Human Reproduction and Embryology

Is the mouse a good model for the human with respect to the development of the preimplantation embryo in vitro?

Patrick Quinn1,2 and Frederick C. Horstman1,3

1 Advanced Reproductive Technologies, Inc. San Clemente, USA 2 IVF Laboratory, Alvarado Hospital Medical Center San Diego, California, USA

Correspondence: 3To whom correspondence should be addressed at: 944 Calle Amanecer, Suite L, San Clemente, CA 92673, USA

A comparison has been made of various aspects of preimplantation development of mouse and human embryos in vitro. Changes in substrate utilization follow similar patterns in both species. This similarity in metabolic parameters between the two species has facilitated the use of the mouse as a model to study the formulation of culture media to be used at different stages over the preimplantation period from fertilization to the fully expanded blastocyst stage. It has also prescribed the mouse embryo as a practical tool for quality control testing of the laboratory system in human in-vitro fertilization. Aspects of the physiology of both species that require further study are the physiological levels of endogenous inorganic phosphate in the female reproductive tract, the requirement for inorganic phosphate in culture medium, the specificity of the amino acid requirements for optimal development before and after compaction and the importance of including EDTA in culture medium.

Key words: culture/embryo transfer/IVF/mouse/preimplantation embryo


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