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Human Reproduction, Vol. 13, No. suppl_4, pp. 31-46, 1998
© 1998 European Society of Human Reproduction and Embryology

Role of integrins during fertilization in mammals

P. Fénichel1 and M. Durand-Clément

Groupe de Recherche sur l'Interaction Gamétique CJF-INSERM 95–04, Faculté de Médecine, 06107 Nice Cedex 2, France

Correspondence: 1To whom correspondence should be addressed

Fertilization includes sperm–oocyte recognition, adhesion, binding, fusion and egg activation. Integrin receptors, which are adhesion molecules, are expressed on sea urchin, mouse, hamster and human unfertilized oocytes. Potential sperm ligands have been identified. A role for integrins during fertilization is supported by inhibition of sperm–egg adhesion and/or fusion by means of anti-integrin monoclonal antibodies, Arg-Gly-Asp (RGD) or disintegrin-like peptides. In several cell–cell interactions, such as lymphocyte activation, viral fusion, bacterial infection or macrophage phagocytosis, integrins act as co-receptors after activation and, by clustering in a multi-molecular complex, are able to transduce signals through cytoskeletal proteins and adaptor kinases. Experimental data suggest that they may act in a similar way during fertilization and may participate to initiation and/or propagation of the calcium signal via stimulation of phospholipase C{gamma} and inositol trisphosphate production.

Key words: adhesion/cytoskeleton/fertilization/integrin/sperm-oocyte interaction


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