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Human Reproduction, Vol. 14, No. 1, 156-161, January 1999
© 1999 European Society of Human Reproduction and Embryology

Are there any relationships between the fecundity of bilateral ovaries in an individual patient and the incidence of apoptotic granulosa cells?

Philippe Moreira1,2,3, Hidekazu Saito1,4, Tomoko Kaneko1, Takakazu Saito1, Kenji Nakahara1 and Masahiko Hiroi1

1 Department of Obstetrics and Gynecology, Yamagata University School of Medicine, 2–2–2 Iida Nishi Yamagata 990–9585, Japan and 2 Department of Obstetrics and Gynecology, Dakar University, Senegal

Many researchers have discussed fecundity on a per patient or per ovarian follicle basis. In contrast, this study was undertaken on a per ovary basis, and tests the hypothesis that there is a relationship between the fecundity of the bilateral ovaries in an individual patient and the incidence of apoptotic granulosa cells. The two ovaries of 10 women undergoing ovulation induction for in-vitro fertilization (IVF) with gonadotrophin-releasing hormone analogue (GnRHa) and gonadotrophins were compared. There was no difference in apoptotic index in granulosa cells and various hormones in the follicular fluids. Our results indicate that, in the ovulation induction protocol for IVF, GnRHa and gonadotrophins, there is no predisposition of one ovary over the other in an individual patient in terms of apoptosis at the time of aspiration, even though the number of oocytes in each ovary is different, because the number of oocytes retrieved may reveal ovarian fecundity before stimulation with GnRHa + human menopausal gonadotrophin (HMG).

Key words: apoptosis/granulosa cells/human/in-vitro fertilization

3 Current address: BP 22394 Dakar – Ponty, Senegal

4 To whom correspondence should be addressed


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