Human Reproduction, Vol. 14, No. 11, 2727-2730,
November 1999
© 1999 European Society of Human Reproduction and Embryology
Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study
1 Departments of Obstetrics and Gynaecology and 2 Histopathology, Imperial College School of Medicine at St Mary's, London W2 1NY, UK
Endometrial natural killer (NK) cells were compared in luteal-phase endometrial samples from women with recurrent miscarriage and from normal subjects. Cryostat sections were labelled using a monoclonal antibody to CD56 using an avidin–biotin complex method and a morphometric study performed. Increased mean numbers of CD56+ cells were documented in the endometrium of women with recurrent early miscarriage only. These findings suggest a possible role for NK cells in the pathogenesis of recurrent early pregnancy loss.
Key words: endometrium/natural killer cells/recurrent miscarriage
3 To whom correspondence should be addressed
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