Human Reproduction, Vol. 14, No. 11, 2755-2758,
November 1999
© 1999 European Society of Human Reproduction and Embryology
Donor age is paramount to success in oocyte donation *
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, New York Presbyterian Medical Center, College of Physicians and Surgeons, Columbia University, New York, USA
Several reports suggest increasing age in oocyte donors decreases the chances of in-vitro fertilization (IVF) success, while others describe no effect. The published data concerning gravidity and parity are similarly conflicting. To further address these questions, we retrospectively studied 445 consecutive donor IVF cycles at two large university-based IVF practices. Donor cycles were analysed for the number of oocytes retrieved, gravidity, parity, and age of the donor, and pregnancy outcome in recipients. The previous gravidity and parity of the donor were not associated with successful pregnancy in recipients. The number of oocytes retrieved was positively correlated with pregnancy. However, after adjusting for donor age, neither prior fertility nor the number of oocytes retrieved were significant predictors. In contrast, the donor's age was highly associated with recipient success. We conclude that the age of the oocyte donor is a significant predictor of pregnancy success and should be a major factor in selecting prospective candidates. The gravidity and parity of the donor are insignificant predictors, as are the total number of oocytes retrieved at the time of oocyte harvest.
Key words: age/gravidity/in-vitro fertilization/oocyte donor/parity
1 To whom correspondence should be addressed at: Columbia Presbyterian Medical Center, Department of Obstetrics and Gynecology, 622 West 168th Street, New York, NY 10032, USA
* Presented at the 54th Annual Meeting of the American Society of Reproductive Medicine, San Francisco, CA, USA, October 4–9, 1998
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