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Human Reproduction, Vol. 14, No. 2, 375-378, February 1999
© 1999 European Society of Human Reproduction and Embryology

Meiotic abnormalities and spermatogenic parameters in severe oligoasthenozoospermia

J.M. Vendrell1,3, F. García1, A. Veiga1, G. Calderón1, S. Egozcue2, J. Egozcue2 and P.N. Barri1

1 Reproductive Medicine Service, Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Universitat Autònoma de Barcelona, Passeig Bonanova 67, E-08017 Barcelona and 2 Department of Cellular Biology and Physiology, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain

The incidence of meiotic abnormalities and their relationship with different spermatogenic parameters was assessed in 103 male patients with presumably idiopathic severe oligoasthenozoospermia (motile sperm concentration <=1.5x106/ml). Meiosis on testicular biopsies was independently evaluated by two observers. Meiotic patterns included normal meiosis and two meiotic abnormalities, i.e. severe arrest and synaptic anomalies. A normal pattern was found in 64 (62.1%), severe arrest in 21 (20.4%) and synaptic anomalies in 18 (17.5%). The overall rate of meiotic abnormalities was 37.9%. Most (66.7%) meiotic abnormalities occurred in patients with a sperm concentration <=1x106/ml. In this group, total meiotic abnormalities were found in 57.8% of the patients; of these, 26.7% had synaptic anomalies. When the sperm concentration was <=0.5x106/ml, synaptic anomalies were detected in 40% of the patients. In patients with increased follicle stimulating hormone (FSH) concentrations, total meiotic abnormalities occurred in 54.8% (synaptic anomalies in 22.6%). There were statistically significant differences among the three meiotic patterns in relation to sperm concentration (P < 0.001) and serum FSH concentration (P < 0.05). In the multivariate analysis, sperm concentration <=1x106/ml and/or FSH concentration >10 IU/l were the only predictors of meiotic abnormalities.

Key words: intracytoplasmic sperm injection /meiosis/meiotic chromosome abnormalities/oligoasthenozoospermia/sperm parameters

3 To whom correspondence should be addressed


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